Fig. 4
From: N/OFQ modulates orofacial pain induced by tooth movement through CGRP-dependent pathways
The effects of N/OFQ receptor agonist and antagonist on CGRP expressions. The rats were respectively injected with N/OFQ receptor agonist (N/OFQ), antagonist (UFP-101) and normal saline (NS) after 40-g spring placement (n = 18 for each group, n = 3 for each group each day). a CGRP immunostaining in trigeminal ganglion of rats in NS group, N/OFQ group and UFP-101 group (3rd day). The images were acquired at the resolution of 300dpi. b Western blot analysis of CGRP expression in trigeminal ganglion of rats in NS group, N/OFQ group and UFP-101 group using WES. The images were cropped using Adobe Photoshop software, and full-length blots/gels are presented in Additional file 3: Figure S2. c Temporal changes of CGRP expression level in NS group, N/OFQ group and UFP-101 group. One-way ANOVA with Bonferroni post hoc test was employed to analyze the effects of N/OFQ, UFP-101 and NS on CGRP expressions. (*p < 0.05, NS group vs. N/OFQ group, NS group vs. UFP-101 group, N/OFQ group vs. UFP-101 group)