Fig. 3
From: N/OFQ modulates orofacial pain induced by tooth movement through CGRP-dependent pathways
The effects of N/OFQ receptor agonist and antagonist on pain modulation. The rats were respectively injected with N/OFQ receptor agonist (N/OFQ), antagonist (UFP-101) and normal saline (NS) after 40-g spring placement (n = 8 for each group). Temporal changes of RGS scores in NS group, N/OFQ group and UFP-101 group were shown in the figure. One-way ANOVA with Bonferroni post hoc test was employed to analyze the effects of N/OFQ, UFP-101 and NS on RGS scores. (**p < 0.01, NS group vs. N/OFQ group, NS group vs. UFP-101 group, N/OFQ group vs. UFP-101 group)