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Table 1 Summary of behavioral tests, oxytocin concentrations and effects of oxytocin in Chd8+/∆SL mice

From: Oxytocin ameliorates impaired social behavior in a Chd8 haploinsufficiency mouse model of autism

Parameter Test Phenotype Oxytocin effect
Locomotion Open field Normal  
Social Avoidance Social avoidance test Normal  
Anxiety Social avoidance test
Elevated plus maze
Light dark box
Reverse light dark box
Anxious Corrected in males in light dark box
Sociability 3-chamber box Normal  
Social preference 3-chamber box Absence in males
Increased to novelty in females
Depression Sucrose preference
Tail suspension test
Depressive phenotype in females  
Oxytocin concentration   Decreased in males