Fig. 4
From: Oxytocin ameliorates impaired social behavior in a Chd8 haploinsufficiency mouse model of autism
Role of oxytocin in Chd8+/∆SL mice. a The concentration of oxytocin (OT) in deproteinized plasma of wild-type (WT) and Chd8 (Chd8±) mice. b Effect of saline (PBS) or OT on the behavior of WT and Chd8+/∆SL mice in the light–dark transition test starting from the light zone. b Time spent in the light zone. c–f Effect of saline (PBS) or OT on the behavior of WT and Chd8+/∆SL mice in the three-chamber box test. Cumulative heatmaps for sociability phase (c), the ratio for social novelty (d), cumulative heatmaps for social preference phase (e), and ratio for social preference (f). Columns with different superscript letters (a–d) are significantly different at p < 0.05