Lung-protective ventilation increases cerebral metabolism and non-inflammatory brain injury in porcine experimental sepsis

Nyberg, Axel; Gremo, Erik; Blixt, Jonas; Sperber, Jesper; Larsson, Anders; Lipcsey, Miklós; Pikwer, Andreas; Castegren, Markus

doi:10.1186/s12868-021-00629-0

Table 1 Physiologic data during the experiment

From: Lung-protective ventilation increases cerebral metabolism and non-inflammatory brain injury in porcine experimental sepsis

	Group	0	1	2	3	4	5	6	p
TVe	Low V_T	163 ± 16	163 ± 15	163 ± 15	164 ± 15	166 ± 11	165 ± 12	165 ± 11	0.001
(cmH₂0)	Medium high V_T	244 ± 35	247 ± 37	245 ± 37	248 ± 38	247 ± 37	247 ± 37	247 ± 38
RR	Low V_T	46 ± 3	46 ± 4	48 ± 5	48 ± 5	48 ± 5	48 ± 5	48 ± 5	0.001
(min^-1)	Medium high V_T	24 ± 5	24 ± 5	24 ± 5	24 ± 5	24 ± 5	24 ± 5	24 ± 5
P Peak	Low V_T	19 ± 2	20 ± 2	20 ± 2	21 ± 1	21 ± 2	21 ± 2	21 ± 2	0.04
(cmH₂0)	Medium high V_T	21 ± 1	22 ± 1	22 ± 2	22 ± 2	22 ± 2	22 ± 2	23 ± 2
Compliance	Low V_T	23 ± 8	24 ± 8	22 ± 5	21 ± 6	21 ± 5	21 ± 4	19 ± 3	0.06
(mL x cmH₂0^-1)	Medium high V_T	30 ± 6	27 ± 8	26 ± 7	26 ± 6	26 ± 5	25 ± 4	24 ± 5
PaO₂	Low V_T	19.0 ± 1.2	15.8 ± 3.1	17.1 ± 2.2	15.3 ± 3.3	15.1 ± 2.9	15.4 ± 2.6	15.1 ± 2.9	0.16
(kPa)	Medium high V_T	19.3 ± 1.5	17.8 ± 2.8	16.5 ± 3.8	16.5 ± 3.8	16.0 ± 3.8	17.7 ± 2.7	17.0 ± 2.3
PaCO₂	Low V_T	5.6 ± 0.4	6.2 ± 0.7	5.6 ± 0.3	5.6 ± 0.4	5.5 ± 0.6	5.3 ± 0.5	5.3 ± 0.5	0.15
(kPa)	Medium high V_T	5.1 ± 0.3	5.6 ± 0.5	5.5 ± 0.5	5.5 ± 0.5	5.3 ± 0.3	5.3 ± 0.6	5.2 ± 0.3
PaO₂/FiO₂	Low V_T	475 ± 31	395 ± 80	427 ± 55	381 ± 82	373 ± 80	380 ± 74	348 ± 78	0.66
(mmHg)	Medium high V_T	484 ± 38	421 ± 120	404 ± 80	385 ± 76	405 ± 90	410 ± 75	379 ± 89
Temp	Low V_T	38.1 ± 0.4	38.3 ± 0.6	38.5 ± 0.8	38.8 ± 0.9	38.8 ± 0.9	38.7 ± 1.1	38.7 ± 1.1	0.29
(°)	Medium high V_T	38.3 ± 0.8	38.8 ± 1.2	39.2 ± 1.4	39.4 ± 1.6	39.5 ± 1.9	39.5 ± 1.9	39.4 ± 2.1
HR	Low V_T	95 ± 25	106 ± 21	102 ± 15	111 ± 24	104 ± 18	104 ± 17	105 ± 16	0.45
(min^-1)	Medium high V_T	97 ± 17	110 ± 26	111 ± 21	108 ± 18	110 ± 21	111 ± 21	125 ± 29
MAP	Low V_T	83 ± 13	83 ± 19	96 ± 13	95 ± 20	92 ± 18	84 ± 19	83 ± 19	0.69
(mmHg)	Medium high V_T	89 ± 11	95 ± 18	98 ± 17	98 ± 13	91 ± 19	83 ± 16	77 ± 15
MPAP	Low V_T	18 ± 3	37 ± 8	31 ± 5	35 ± 9	30 ± 7	28 ± 7	27 ± 7	0.15
(mmHg)	Medium high V_T	19 ± 3	33 ± 9	30 ± 6	29 ± 6	25 ± 4	23 ± 4	24 ± 3
ICP	Low V_T	12 ± 6	17 ± 6	18 ± 7	21 ± 10	23 ± 9	25 ± 13	26 ± 15	0.72
(mmHg)	Medium high V_T	17 ± 12	17 ± 7	19 ± 8	18 ± 6	17 ± 4	16 ± 4	18 ± 5
CI	Low V_T	3.4 ± 1.2	3.5 ± 1.2	3.2 ± 0.8	2.9 ± 0.9	2.9 ± 0.9	3.1 ± 0.7	3.2 ± 0.8	0.24
(L x min^-1 x m^-2)	Medium high V_T	3.4 ± 0.5	2.8 ± 0.7	2.6 ± 0.5	2.5 ± 0.6	2.6 ± 0.5	2.8 ± 0.7	2.8 ± 0.6
Lactate	Low V_T	1.6 ± 0.6	1.5 ± 0.8	1.1 ± 0.5	1.2 ± 0.6	1.3 ± 0.6	1.1 ± 0.4	0.9 ± 0.3	0.95
(mmol x L^-1)	Medium high V_T	1.4 ± 0.3	1.8 ± 1.3	1.3 ± 0.3	1.3 ± 0.5	1.0 ± 0.3	0.9 ± 0.2	0.9 ± 0.2
Diuresis	Low V_T		40(25–50)	70(38–180)	90(55–170)	111(80–500)	175(60–340)	180(65–390)	0.71
(mL x h^-1)	Medium high V_T		95(50–160)	105(50–180)	160(80–270)	70(55–180)	90(40–290)	95(40–290)

Values are mean ± SE or median (interquartile range). The p-values are results of general linear models with random effects. A p value of < 0.05 was considered significant
TVe expired tidal volume, RR respiratory rate, P Peak peak airway pressure, Compliance-Static airway compliance, PaO₂ arterial partial pressure of oxygen, PaCO₂ arterial partial pressure of carbon dioxide, PaO₂/FiO₂ arterial partial pressure of oxygen to fraction of inspired oxygen, Temp core body temperature, HR heart rate, MAP mean arterial pressure, MPAP mean pulmonary arterial pressure, ICP intracranial pressure, CI cardiac index

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