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Table 1 Physiologic data during the experiment

From: Lung-protective ventilation increases cerebral metabolism and non-inflammatory brain injury in porcine experimental sepsis

  Group 0 1 2 3 4 5 6 p
TVe Low VT 163 ± 16 163 ± 15 163 ± 15 164 ± 15 166 ± 11 165 ± 12 165 ± 11 0.001
 (cmH20) Medium high VT 244 ± 35 247 ± 37 245 ± 37 248 ± 38 247 ± 37 247 ± 37 247 ± 38  
RR Low VT 46 ± 3 46 ± 4 48 ± 5 48 ± 5 48 ± 5 48 ± 5 48 ± 5 0.001
 (min-1) Medium high VT 24 ± 5 24 ± 5 24 ± 5 24 ± 5 24 ± 5 24 ± 5 24 ± 5  
P Peak Low VT 19 ± 2 20 ± 2 20 ± 2 21 ± 1 21 ± 2 21 ± 2 21 ± 2 0.04
(cmH20)  Medium high VT 21 ± 1 22 ± 1 22 ± 2 22 ± 2 22 ± 2 22 ± 2 23 ± 2  
Compliance Low VT 23 ± 8 24 ± 8 22 ± 5 21 ± 6 21 ± 5 21 ± 4 19 ± 3 0.06
(mL x cmH20-1 Medium high VT 30 ± 6 27 ± 8 26 ± 7 26 ± 6 26 ± 5 25 ± 4 24 ± 5  
PaO2 Low VT 19.0 ± 1.2 15.8 ± 3.1 17.1 ± 2.2 15.3 ± 3.3 15.1 ± 2.9 15.4 ± 2.6 15.1 ± 2.9 0.16
 (kPa) Medium high VT 19.3 ± 1.5 17.8 ± 2.8 16.5 ± 3.8 16.5 ± 3.8 16.0 ± 3.8 17.7 ± 2.7 17.0 ± 2.3  
PaCO2 Low VT 5.6 ± 0.4 6.2 ± 0.7 5.6 ± 0.3 5.6 ± 0.4 5.5 ± 0.6 5.3 ± 0.5 5.3 ± 0.5 0.15
(kPa) Medium high VT 5.1 ± 0.3 5.6 ± 0.5 5.5 ± 0.5 5.5 ± 0.5 5.3 ± 0.3 5.3 ± 0.6 5.2 ± 0.3  
PaO2/FiO2 Low VT 475 ± 31 395 ± 80 427 ± 55 381 ± 82 373 ± 80 380 ± 74 348 ± 78 0.66
(mmHg)  Medium high VT 484 ± 38 421 ± 120 404 ± 80 385 ± 76 405 ± 90 410 ± 75 379 ± 89  
Temp Low VT 38.1 ± 0.4 38.3 ± 0.6 38.5 ± 0.8 38.8 ± 0.9 38.8 ± 0.9 38.7 ± 1.1 38.7 ± 1.1 0.29
(°) Medium high VT 38.3 ± 0.8 38.8 ± 1.2 39.2 ± 1.4 39.4 ± 1.6 39.5 ± 1.9 39.5 ± 1.9 39.4 ± 2.1  
HR Low VT 95 ± 25 106 ± 21 102 ± 15 111 ± 24 104 ± 18 104 ± 17 105 ± 16 0.45
(min-1 Medium high VT 97 ± 17 110 ± 26 111 ± 21 108 ± 18 110 ± 21 111 ± 21 125 ± 29  
MAP Low VT 83 ± 13 83 ± 19 96 ± 13 95 ± 20 92 ± 18 84 ± 19 83 ± 19 0.69
(mmHg) Medium high VT 89 ± 11 95 ± 18 98 ± 17 98 ± 13 91 ± 19 83 ± 16 77 ± 15  
MPAP Low VT 18 ± 3 37 ± 8 31 ± 5 35 ± 9 30 ± 7 28 ± 7 27 ± 7 0.15
(mmHg)  Medium high VT 19 ± 3 33 ± 9 30 ± 6 29 ± 6 25 ± 4 23 ± 4 24 ± 3  
ICP Low VT 12 ± 6 17 ± 6 18 ± 7 21 ± 10 23 ± 9 25 ± 13 26 ± 15 0.72
(mmHg) Medium high VT 17 ± 12 17 ± 7 19 ± 8 18 ± 6 17 ± 4 16 ± 4 18 ± 5  
CI Low VT 3.4 ± 1.2 3.5 ± 1.2 3.2 ± 0.8 2.9 ± 0.9 2.9 ± 0.9 3.1 ± 0.7 3.2 ± 0.8 0.24
 (L x min-1 x m-2) Medium high VT 3.4 ± 0.5 2.8 ± 0.7 2.6 ± 0.5 2.5 ± 0.6 2.6 ± 0.5 2.8 ± 0.7 2.8 ± 0.6  
Lactate Low VT 1.6 ± 0.6 1.5 ± 0.8 1.1 ± 0.5 1.2 ± 0.6 1.3 ± 0.6 1.1 ± 0.4 0.9 ± 0.3 0.95
(mmol x L-1) Medium high VT 1.4 ± 0.3 1.8 ± 1.3 1.3 ± 0.3 1.3 ± 0.5 1.0 ± 0.3 0.9 ± 0.2 0.9 ± 0.2  
Diuresis Low VT   40(25–50) 70(38–180) 90(55–170) 111(80–500) 175(60–340) 180(65–390) 0.71
 (mL x h-1) Medium high VT   95(50–160) 105(50–180) 160(80–270) 70(55–180) 90(40–290) 95(40–290)  
  1. Values are mean ± SE or median (interquartile range). The p-values are results of general linear models with random effects. A p value of < 0.05 was considered significant
  2. TVe expired tidal volume, RR respiratory rate, P Peak peak airway pressure, Compliance-Static airway compliance, PaO2 arterial partial pressure of oxygen, PaCO2 arterial partial pressure of carbon dioxide, PaO2/FiO2 arterial partial pressure of oxygen to fraction of inspired oxygen, Temp core body temperature, HR heart rate, MAP mean arterial pressure, MPAP mean pulmonary arterial pressure, ICP intracranial pressure, CI cardiac index