Fig. 2

The effects of the administration of different doses of VU0155041, as a potent and selective mGluR4 agonist, (10, 30 and 50 μg/0.5 μL) into the NAc 5 min before the injection of morphine (5 mg/kg, sc) and administration of maximum dose of VU0155041 into the NAc region alone, on the conditioning days. Bars represent mean ± S.E.M (Pre-conditioning; n = 8, Saline; n = 6, Vehicle; n = 7, different doses of VU0155041 (10 μg/0.5 μL; n = 11, 30 μg/0.5 μL; n = 10 and 50 μg/0.5 μL; n = 8). *P < 0.05, **P < 0.01, Kruskal Wallis test followed by Dunn's multiple comparisons test