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Table 3 the association between clinical feature and sex in LRRK2 G2385R carriers and non-carriers

From: Sex effects on clinical features in LRRK2 G2385R carriers and non-carriers in Parkinson's disease

  LRRK2 G2385R carriers LRRK2 G2385R non-carriers P-value (all female PD vs. all male PD)
OR (95%CI) p OR (95%CI) p OR (95%CI) p
EOPD 1.701 (0.508–5.693) 0.388 0.841 (0.563–1.256) 0.397 0.904 (0.618–1.321) 0.602
Advanced stage a 1.589 (0.222–11.353) 0.644 1.361 (0.824–2.248) 0.229 1.35 (0.838–2.184) 0.216
Impaired ADL a 0.599 (0.183–1.957) 0.392 0.610 (0.400–0.928) 0.021 0.617 (0.416–0.913) 0.016
Motor dysfunction a 0.750 (0.261–2.153) 0.592 0.695 (0.473–1.019) 0.063 0.698 (0.488–0.999) 0.049
Motor complication a 0.840 (0.201–3.513) 0.812 1.259 (0.720–2.199) 0.419 1.193 (0.714–1.995) 0.500
Cognitive impairment b 1.583 (0.458–5.477) 0.468 0.749 (0.485–1.156) 0.192 0.844 (0.564–1.264) 0.411
Sleep disorder c 2.006 (0.525–7.655) 0.309 1.358 (0.830–2.222) 0.223 1.417 (0.893–2.247) 0.139
Mood disorder c 0.854 (0.211–3.459) 0.825 1.691 (1.078–2.654) 0.022 1.594 (1.041–2.441) 0.032
olfaction c 1.850 (0.618–5.537) 0.271 0.686 (0.463–1.016) 0.060 0.774 (0.536–1.116) 0.170
RBD c 1.558 (0.575–4.218) 0.383 1.224 (0.823–1.821) 0.317 1.278 (0.885–1.844) 0.190
Autonomic dysfunction c 0.294 (0.102–0.849) 0.024 0.626 (0.428–0.917) 0.016 0.574 (0.402–0.820) 0.002
EDS c 1.095 (0.383–3.125) 0.866 0.555 (0.361–0.853) 0.007 0.619 (0.417–0.919) 0.017
Life quality c 1.024 (0.394–2.644) 0.961 1.054 (0.722–1.537) 0.786 1.003 (0.986–1.019) 0.764
SN + c 0.980 (0.149–6.443) 0.983 0.448 (0.228–0.878) 0.019 0.488 (0.260–0.919) 0.026
  1. aAdjusted for age, disease duration and LEDD
  2. bAdjusted for age, disease duration and years of education
  3. cAdjusted for age and disease duration