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Table 2 the association between clinical feature and LRRK2 G2385R in male and female

From: Sex effects on clinical features in LRRK2 G2385R carriers and non-carriers in Parkinson's disease

 

Male

Female

P-value (all G2385R carriers vs. all non-carriers)

OR (95%CI)

p

Genetic power

OR (95%CI)

p

Genetic power

OR (95%CI)

p

EOPD

0.430 (0.174–1.061)

0.067

0.070

0.870 (0.355–2.130)

0.760

0.007

0.595 (0.316–1.120)

0.108

Advanced stage a

0.487 (0.165–1.443)

0.194

0.247

0.360 (0.102–1.273)

0.113

0.177

0.425 (0.189–0.957)

0.039

Impaired ADL a

1.195 (0.557–2.563)

0.647

0.074

1.228 (0.524- 2.877)

0.637

0.078

1.167 (0.665–2.048)

0.591

Motor dysfunction a

1.540 (0.746–3.177)

0.243

0.247

1.647 (0.739- 3.670)

0.166

0.249

1.549 (0.908–2.642)

0.108

Motor complication a

1.779 (0.688- 4.600)

0.234

0.391

1.372 (0.461–4.088)

0.570

0.132

1.557 (0.763–3.180)

0.224

Cognitive impairment b

0.301 (0.135–0.668)

0.003

0.005

0.709 (0.276–1.820)

0.475

0.058

0.448 (0.248–0.809)

0.008

Sleep disorder c

0.857 (0.312–2.357)

0.765

0.077

1.026 (0.385–2.739)

0.959

0.048

1.084 (1.034–1.136)

0.001

Mood disorder c

0.781 (0.305–1.996)

0.605

0.119

0.425 (0.140–1.284)

0.129

0.169

0.587 (0.288–1.198)

0.143

olfaction c

0.605 (0.291–1.255)

0.177

0.141

1.680 (0.702–4.020)

0.244

0.299

0.976 (0.562–1.695)

0.931

RBD c

0.806 (0.386–1.685)

0.567

0.102

1.123 (0.500–2.520)

0.779

0.062

0.926 (0.539–1.592)

0.781

Autonomic dysfunction c

0.879 (0.439–1.762)

0.717

0.070

0.401 (0.167–0.960)

0.040

0.044

0.653 (0.387–1.102)

0.110

EDS c

0.804 (0.379–2.095)

0.571

0.103

1.637 (0.695–3.854)

0.259

1.637

1.070 (0.611–1.875)

0.813

Life quality c

1.050 (0.526–2.095)

0.891

0.048

0.953 (0.437–2.080)

0.903

0.953

1.001 (0.597–1.678)

0.998

SN + c

0.773 (0.236–2.530)

0.670

0.125

1.602 (0.344–7.455)

0.548

1.602

0.988 (0.388–2.519)

0.980

  1. aAdjusted for age, disease duration and LEDD
  2. bAdjusted for age, disease duration and years of education
  3. cAdjusted for age and disease duration
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BMC Neuroscience

ISSN: 1471-2202

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