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Table 2 the association between clinical feature and LRRK2 G2385R in male and female

From: Sex effects on clinical features in LRRK2 G2385R carriers and non-carriers in Parkinson's disease

  Male Female P-value (all G2385R carriers vs. all non-carriers)
OR (95%CI) p Genetic power OR (95%CI) p Genetic power OR (95%CI) p
EOPD 0.430 (0.174–1.061) 0.067 0.070 0.870 (0.355–2.130) 0.760 0.007 0.595 (0.316–1.120) 0.108
Advanced stage a 0.487 (0.165–1.443) 0.194 0.247 0.360 (0.102–1.273) 0.113 0.177 0.425 (0.189–0.957) 0.039
Impaired ADL a 1.195 (0.557–2.563) 0.647 0.074 1.228 (0.524- 2.877) 0.637 0.078 1.167 (0.665–2.048) 0.591
Motor dysfunction a 1.540 (0.746–3.177) 0.243 0.247 1.647 (0.739- 3.670) 0.166 0.249 1.549 (0.908–2.642) 0.108
Motor complication a 1.779 (0.688- 4.600) 0.234 0.391 1.372 (0.461–4.088) 0.570 0.132 1.557 (0.763–3.180) 0.224
Cognitive impairment b 0.301 (0.135–0.668) 0.003 0.005 0.709 (0.276–1.820) 0.475 0.058 0.448 (0.248–0.809) 0.008
Sleep disorder c 0.857 (0.312–2.357) 0.765 0.077 1.026 (0.385–2.739) 0.959 0.048 1.084 (1.034–1.136) 0.001
Mood disorder c 0.781 (0.305–1.996) 0.605 0.119 0.425 (0.140–1.284) 0.129 0.169 0.587 (0.288–1.198) 0.143
olfaction c 0.605 (0.291–1.255) 0.177 0.141 1.680 (0.702–4.020) 0.244 0.299 0.976 (0.562–1.695) 0.931
RBD c 0.806 (0.386–1.685) 0.567 0.102 1.123 (0.500–2.520) 0.779 0.062 0.926 (0.539–1.592) 0.781
Autonomic dysfunction c 0.879 (0.439–1.762) 0.717 0.070 0.401 (0.167–0.960) 0.040 0.044 0.653 (0.387–1.102) 0.110
EDS c 0.804 (0.379–2.095) 0.571 0.103 1.637 (0.695–3.854) 0.259 1.637 1.070 (0.611–1.875) 0.813
Life quality c 1.050 (0.526–2.095) 0.891 0.048 0.953 (0.437–2.080) 0.903 0.953 1.001 (0.597–1.678) 0.998
SN + c 0.773 (0.236–2.530) 0.670 0.125 1.602 (0.344–7.455) 0.548 1.602 0.988 (0.388–2.519) 0.980
  1. aAdjusted for age, disease duration and LEDD
  2. bAdjusted for age, disease duration and years of education
  3. cAdjusted for age and disease duration