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Table 4 Neuropsychological assessment of SYNE1 and Friedreich ataxia patients

From: Eye-tracking-aided characterization of saccades and antisaccades in SYNE1 ataxia patients: a pilot study

Patient code Age (years) Education (years) ACE (93.7 ± 4.3) MMSE (28.8 ± 1.3) LST BDST Verbal fluency Semantic fluency RCFT copying RCFT recall
SYNE1 patients
 AT-04 35 14 89 29 2 (3.38 ± 0.79)a 4 (5.88 ± 1.1)a 10.5 (17.61 ± 5.42)a 14 (17.25 ± 3.96) NA NA
 AT-05 43 14 93 29 2.33 (3.38 ± 0.79)a 3 (5.88 ± 1.1)b 14.5 (17.61 ± 5.42) 17 (17.25 ± 3.96) 35 (31.1 ± 3.6) 15 (23.7 ± 5.2)a
 AT-06 37 12 89 29 2 (3.38 ± 0.79)a 2 (5.88 ± 1.1)c 16 (17.61 ± 5.42) 14 (17.25 ± 3.96) 36 (31.1 ± 3.6) 21.5 (23.7 ± 5.2)
Friedreich ataxia patients
 AT-08 23 12.5 93 30 3 (3.45 ± 0.89) 4 (5.88 ± 1.1)a 14.5 (16.13 ± 5.65) 11 (15.84 ± 4.51) 36 (31.1 ± 3.6) 24 (23.7 ± 5.2)
 AT-11 57 16 87a 27 2.33 (3.11 ± 0.61)a 3 (5.34 ± 0.96)b 12 (11.02 ± 4.98) 16 (13.77 ± 4.05) 36 (29.2 ± 4.2) 26.5 (15.5 ± 5.5)
 AT-12 60 17 95 29 3 (3.11 ± 0.61) 2 (5.34 ± 0.96)c 15.5 (11.02 ± 4.98) 20 (13.77 ± 4.05) 34 (29.2 ± 4.2) 27 (15.5 ± 5.5)
 AT-20 16 10 88 26a 2.66 (3.33 ± 0.59) 5 (5.88 ± 0.96) 13.5 (13.83 ± 4.31) 14 (13.44 ± 3.52) 36 (31.1 ± 3.6) 26 (23.7 ± 5.2)
 AT-21 59 14 94 30 3 (3.11 ± 0.61) 5 (5.34 ± 0.96) 15 (11.02 ± 4.98) 14 (13.77 ± 4.05) 32 (29.2 ± 4.2) 17.5 (15.5 ± 5.5)
 AT-22 34 15 96 30 3.3 (3.38 ± 0.79) 4 (5.88 ± 1.1)a 16.5 (16.13 ± 5.65) 21 (15.84 ± 4.51) 34 (31.1 ± 3.6) 21 (23.7 ± 5.2)
  1. In ACE and MMSE the lower normal threshold values of the normal population are in the brackets
  2. In LST, BDST, verbal fluency, semantic fluency, RCFT copying and RCFT recall the age- and education-matched lower threshold values of the normal population are in the brackets
  3. ACE Addenbrooke’s Cognitive Examination, BDST Backward Digit Span Task, LST Listening Span Task, MMSE Mini-Mental State Examination, NA not available, RCFT Rey Complex Figure Test
  4. aMild deficit, bmoderate deficit, csevere deficit (Age- and education-matched standards, and standard deviations of the literature are delineated [23,24,25]. Mild, moderate and severe deficits mean that the cognitive impairment of the subject is more pronounced than one, two and three standard deviations of the normal standards, respectively)