Eye-tracking-aided characterization of saccades and antisaccades in SYNE1 ataxia patients: a pilot study

BMC Neuroscience

Table 4 Neuropsychological assessment of SYNE1 and Friedreich ataxia patients

Patient code	Age (years)	Education (years)	ACE (93.7 ± 4.3)	MMSE (28.8 ± 1.3)	LST	BDST	Verbal fluency	Semantic fluency	RCFT copying	RCFT recall
SYNE1 patients
AT-04	35	14	89	29	2 (3.38 ± 0.79)^a	4 (5.88 ± 1.1)^a	10.5 (17.61 ± 5.42)^a	14 (17.25 ± 3.96)	NA	NA
AT-05	43	14	93	29	2.33 (3.38 ± 0.79)^a	3 (5.88 ± 1.1)^b	14.5 (17.61 ± 5.42)	17 (17.25 ± 3.96)	35 (31.1 ± 3.6)	15 (23.7 ± 5.2)^a
AT-06	37	12	89	29	2 (3.38 ± 0.79)^a	2 (5.88 ± 1.1)^c	16 (17.61 ± 5.42)	14 (17.25 ± 3.96)	36 (31.1 ± 3.6)	21.5 (23.7 ± 5.2)
Friedreich ataxia patients
AT-08	23	12.5	93	30	3 (3.45 ± 0.89)	4 (5.88 ± 1.1)^a	14.5 (16.13 ± 5.65)	11 (15.84 ± 4.51)	36 (31.1 ± 3.6)	24 (23.7 ± 5.2)
AT-11	57	16	87^a	27	2.33 (3.11 ± 0.61)^a	3 (5.34 ± 0.96)^b	12 (11.02 ± 4.98)	16 (13.77 ± 4.05)	36 (29.2 ± 4.2)	26.5 (15.5 ± 5.5)
AT-12	60	17	95	29	3 (3.11 ± 0.61)	2 (5.34 ± 0.96)^c	15.5 (11.02 ± 4.98)	20 (13.77 ± 4.05)	34 (29.2 ± 4.2)	27 (15.5 ± 5.5)
AT-20	16	10	88	26^a	2.66 (3.33 ± 0.59)	5 (5.88 ± 0.96)	13.5 (13.83 ± 4.31)	14 (13.44 ± 3.52)	36 (31.1 ± 3.6)	26 (23.7 ± 5.2)
AT-21	59	14	94	30	3 (3.11 ± 0.61)	5 (5.34 ± 0.96)	15 (11.02 ± 4.98)	14 (13.77 ± 4.05)	32 (29.2 ± 4.2)	17.5 (15.5 ± 5.5)
AT-22	34	15	96	30	3.3 (3.38 ± 0.79)	4 (5.88 ± 1.1)^a	16.5 (16.13 ± 5.65)	21 (15.84 ± 4.51)	34 (31.1 ± 3.6)	21 (23.7 ± 5.2)

In ACE and MMSE the lower normal threshold values of the normal population are in the brackets
In LST, BDST, verbal fluency, semantic fluency, RCFT copying and RCFT recall the age- and education-matched lower threshold values of the normal population are in the brackets
ACE Addenbrooke’s Cognitive Examination, BDST Backward Digit Span Task, LST Listening Span Task, MMSE Mini-Mental State Examination, NA not available, RCFT Rey Complex Figure Test
^aMild deficit, ^bmoderate deficit, ^csevere deficit (Age- and education-matched standards, and standard deviations of the literature are delineated [23,24,25]. Mild, moderate and severe deficits mean that the cognitive impairment of the subject is more pronounced than one, two and three standard deviations of the normal standards, respectively)

ISSN: 1471-2202