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Table 5 Subgroup analyses on the association between eosinophil-to-monocyte ratio (EMR) and poor outcome of ischemic stroke

From: Eosinophil-to-monocyte ratio is a potential biomarker in the prediction of functional outcome among patients with acute ischemic stroke

Subgroup

No. of participants

OR (95% CI)

p value

p for interaction

Age, years

0.2716

 < 65

179

0.37 (0.04, 3.57)

0.3900

 

 ≥ 65

342

0.08 (0.02, 0.35)

0.0008

 

Sex

0.1422

 Male

289

0.08 (0.02, 0.43)

0.0033

 

 Female

232

0.05 (0.01, 0.28)

0.0010

 

Hypertension

0.4943

 No

76

35.05 (0.00, Inf)

0.9999

 

 Yes

445

0.08 (0.02, 0.35)

0.0006

 

Diabetes

0.4333

 No

394

0.11 (0.03, 0.40)

0.0008

 

 Yes

127

0.00 (0.00, 0.04)

0.0027

 

Hyperlipidemia

0.8288

 No

312

0.13 (0.02, 0.71)

0.0187

 

 Yes

209

0.05 (0.00, 0.62)

0.0202

 

Previous stroke

0.1904

 No

425

0.06 (0.01, 0.26)

0.0002

 

 Yes

96

0.23 (0.01, 8.31)

0.4233

 

Coronary heart disease

0.5110

 No

470

0.08 (0.02, 0.32)

0.0004

 

 Yes

51

Infa (0.00, Infa)

0.9997

 

Atrial fibrillation

0.5915

 No

435

0.08 (0.02, 0.34)

0.0008

 

 Yes

86

0.10 (0.01, 2.02)

0.1344

 

Current cigarette smoking

0.7324

 No

467

0.09 (0.02, 0.35)

0.0004

 

 Yes

54

0.00 (0.00, Infa)

0.9992

 

NIHSS

0.0023

 < 4

295

0.00 (0.00, 0.03)

0.0006

 

 ≥ 4

226

0.37 (0.12, 1.12)

0.0789

 

Stroke subtypes

0.9674

 Large artery atherosclerosis

188

0.13 (0.02, 0.81)

0.02856

 

 Cardioembolic stroke

77

0.13 (0.01, 2.35)

0.1659

 

 Small artery disease

250

0.06 (0.00, 0.73)

0.0280

 

 Other etiology/unknown

6

Infa

  

IV rtPA

0.7945

 No

476

0.09 (0.02, 0.34)

0.0005

 

 Yes

45

0.00 (0.00, Infa)

0.9993

 

Proton pump inhibitors

0.3518

 No

308

0.03 (0.00, 0.26)

0.0016

 

 Yes

213

0.19 (0.04, 0.91)

0.0381

 
  1. In the multivariate models, confounding factors, such as age, sex, history of hyperlipidemia, history of previous stroke, history of atrial fibrillation, ischemic stroke subtypes, triglyceride, NIHSS score at baseline, premorbid mRS score and proton pump inhibitors treatment were included unless the variable was used as a stratification variable
  2. EMR eosinophil-to-monocyte ratio, IQR interquartile range, IV rtPA intravenous recombinant tissue plasminogen activator, NIHSS National Institutes of Health Stroke Scale, OR odds ratio
  3. aThe model failed because of the small sample size