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Table 5 Subgroup analyses on the association between eosinophil-to-monocyte ratio (EMR) and poor outcome of ischemic stroke

From: Eosinophil-to-monocyte ratio is a potential biomarker in the prediction of functional outcome among patients with acute ischemic stroke

Subgroup No. of participants OR (95% CI) p value p for interaction
Age, years 0.2716
 < 65 179 0.37 (0.04, 3.57) 0.3900  
 ≥ 65 342 0.08 (0.02, 0.35) 0.0008  
Sex 0.1422
 Male 289 0.08 (0.02, 0.43) 0.0033  
 Female 232 0.05 (0.01, 0.28) 0.0010  
Hypertension 0.4943
 No 76 35.05 (0.00, Inf) 0.9999  
 Yes 445 0.08 (0.02, 0.35) 0.0006  
Diabetes 0.4333
 No 394 0.11 (0.03, 0.40) 0.0008  
 Yes 127 0.00 (0.00, 0.04) 0.0027  
Hyperlipidemia 0.8288
 No 312 0.13 (0.02, 0.71) 0.0187  
 Yes 209 0.05 (0.00, 0.62) 0.0202  
Previous stroke 0.1904
 No 425 0.06 (0.01, 0.26) 0.0002  
 Yes 96 0.23 (0.01, 8.31) 0.4233  
Coronary heart disease 0.5110
 No 470 0.08 (0.02, 0.32) 0.0004  
 Yes 51 Infa (0.00, Infa) 0.9997  
Atrial fibrillation 0.5915
 No 435 0.08 (0.02, 0.34) 0.0008  
 Yes 86 0.10 (0.01, 2.02) 0.1344  
Current cigarette smoking 0.7324
 No 467 0.09 (0.02, 0.35) 0.0004  
 Yes 54 0.00 (0.00, Infa) 0.9992  
NIHSS 0.0023
 < 4 295 0.00 (0.00, 0.03) 0.0006  
 ≥ 4 226 0.37 (0.12, 1.12) 0.0789  
Stroke subtypes 0.9674
 Large artery atherosclerosis 188 0.13 (0.02, 0.81) 0.02856  
 Cardioembolic stroke 77 0.13 (0.01, 2.35) 0.1659  
 Small artery disease 250 0.06 (0.00, 0.73) 0.0280  
 Other etiology/unknown 6 Infa   
IV rtPA 0.7945
 No 476 0.09 (0.02, 0.34) 0.0005  
 Yes 45 0.00 (0.00, Infa) 0.9993  
Proton pump inhibitors 0.3518
 No 308 0.03 (0.00, 0.26) 0.0016  
 Yes 213 0.19 (0.04, 0.91) 0.0381  
  1. In the multivariate models, confounding factors, such as age, sex, history of hyperlipidemia, history of previous stroke, history of atrial fibrillation, ischemic stroke subtypes, triglyceride, NIHSS score at baseline, premorbid mRS score and proton pump inhibitors treatment were included unless the variable was used as a stratification variable
  2. EMR eosinophil-to-monocyte ratio, IQR interquartile range, IV rtPA intravenous recombinant tissue plasminogen activator, NIHSS National Institutes of Health Stroke Scale, OR odds ratio
  3. aThe model failed because of the small sample size