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Table 6 Physiological quotients between [saliva]/[plasma] and [plasma]/[CSF] of inflammatory proteins important for VASPI

From: The inflammatory profile of cerebrospinal fluid, plasma, and saliva from patients with severe neuropathic pain and healthy controls-a pilot study

Cytokine/chemokine

[Saliva]/[plasma]

[Plasma]/[CSF]

Patients

Healthy controls

Relative to controls

Patients

Healthy controls

Relative to controls

IL-17D

4.57(0.95–8.71)

3.59 (0.92–6.48)

0.07 (0.02–0.16)

0.10 (0.03–0.54)

IL-17F

0.28 (0.02–0.76)

0.19 (0.04–0.77)

14.72 (4.21–46.64)

21.24 (6.06–65.60)

IL-3

3.74 (0.56-12-98)

3.06 (0.53-

2.86 (0.39–19.03)

2.33 (0.36–8.99)

IL-17E-IL-25

0.31 (0.09–0.59)

0.29 (0.01–1.53)

25.74 (4.09-150.27)

40.80 (1.89-150.29)

IL-31

0.24 (0.05–0.40)

0.25 (0.07–0.53)

9.11 (2.86–21.59)

9.68 (1.86–17.31)

IL-17B

7.27 (1.53–12.97)

6.84 (0.89–12.45)

0.31 (0.11–1.68)

0.32 (0.06–0.98)

IL-23

0.38 (0.02–2.73)

0.71 (0.04-7.00)

92.23 (7.1-1027.13)

40.72 (3.43–110.70)

IL-33

0.96 (0.34–2.30)

0.95 (0.20-0.3.06)

2.57 (0.7-11.92)

2.59 (0.42–7.01)

ENA-78

1.61 (0.06–12.87)

3.01 (0.01–29.21)

38.11 (4.2-141.85)

87.81 (2.98–327.60)

VEGF-A

72.43 (15.60-183.01)

40.97 (5.52–76.75)

8.82 (3.95–21.58)

15.53 (4.59–77.95)

IL-7

1.77 (0.59–5.08)

2.26 (0.38–6.11)

4.58 (1.16–9.13)

6.21 (1.49–13.35)

GM-CSF

25.00 (0.83-128.05)

15.31 (3.55–60.26)

4.24 (0.42–23.21)

2.26 (0.64–5.28)

I-309

0.90 (0.24–3.18)

2.19 (0.24–5.35)

1.14 (0.81–1.92)

1.01 (0.69–1.25)

GRO-alpha

8.37 (1.45–44.80)

3.39 (0.18–22.15)

↑*

2.74 (0.98–8.96)

8.37 (0.79–28.08)

↓*

IL-17A-F

0.48 (0.18–1.48)

4.17 (0.07–45.26)

0.75 (0.47–1.39)

0.84 (0.32–1.35)

MIP-5

0.01 (0.00-0.04)

0.01 (0.00-0.04)

20.62 (13.38–37.51)

21.91 (12.96–34.69)

MCP-2

0.16 (0.06–0.30)

0.19 (0.11–0.36)

3.13 (1.58–6.55)

2.95 (2.14–3.95)

Fractalkine

0.33 (0.07–0.97)

0.18 (0.04–0.38)

3.90 (2.25–5.67)

3.91 (2.10–8.37)

IL-6

3.00 (0.15–21.23)

2.21 (0.11–10.40)

1.47 (0.42–2.85)

0.74 (0.09–2.71)

↑*

  1. Data is presented as mean (range) where significant differences between groups (p < 0.05) are denoted with *, see "Regression of class discriminating inflammatory substances" for exact figure