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Table 5 Physiological quotients between [saliva]/[plasma] and [plasma]/[CSF] of significant cytokines for group discrimination

From: The inflammatory profile of cerebrospinal fluid, plasma, and saliva from patients with severe neuropathic pain and healthy controls-a pilot study

Cytokine/chemokine

[Saliva]/[plasma]

[Plasma]/[CSF]

Patient

Healthy control

Relative to controls

Patient

Healthy control

Relative to controls

MIP-1α

0.63 (0.15–1.38)

0.35 (0.02–0.98)

↑*

1.30 (0.78–1.86)

1.21 (0.79–1.89)

IL-6

3.00 (0.15–21.23)

2.21 (0.11–10.40)

1.47 (0.42–2.85)

0.74 (0.09–2.71)

↑*

IL-1β

502.12 (116.60-1764.62)

505.65 (53.26–1665.00)

2.45 (0.48–5.50)

1.63 (0.24–10.82)

↑*

IL-1RA

0.38 (0.20–0.84)

0.40 (0.24–0.71)

10.73 (6.03–24.88)

7.14 (4.20-12.43)

TSLP

0.32 (0.18–0.47)

0.30 (0.12–0.61)

1.55 (0.46–2.70)

1.78 (0.53–3.25)

MIP-3β

0.01 (0.04–0.08)

0.06 (0.03–0.15)

0.85 (0.17–1.90)

0.61 (0.23–1.02)

MIP-1β

0.15 (0.03–0.38)

0.09 (0.02–0.22)

3.70 (1.89–5.90)

3.90 (2.50–6.43)

GRO-alpha

8.37 (1.45–44.80)

3.39 (0.18–22.15)

↑*

2.74 (0.98–8.96)

8.37 (0.79–28.08)

↓*

YKL-40

0.44 (0.11–0.70)

0.38 (0.04–0.74)

0.85 (0.58–1.01)

0.74 (0.55–0.93)

↑*

M-CSF

3.88 (0.94–9.78)

2.56 (1.15–4.21)

1.05 (0.80–1.38)

1.11 (0.62–1.75)

MCP-3

1.22 (0.48–2.63)

1.97 (0.70–4.07)

0.93 (0.59–1.23)

0.83 (0.68–1.07)

IL-18

2.61 (0.20–8.46)

1.15 (0.21–3.09)

122.99 (38.05-306.47)

104.26 (40.78-155.14)

CTACK

0.00 (0.0008–0.005)

0.00 (0.00-0.01)

122.22 (74.08-201.14)

106.56 (51.85–155.60)

IL-13

0.46 (0.13–0.92)

0.59 (0.04–1.18)

5.12 (1.34–11.21)

3.57 (1.25–13.99)

ENA-78

0.06 (1.61–12.87)

3.01 (0.01–29.21)

38.11 (2.20-141.85)

87.81 (2.98–327.60)

  1. Quotients for 15 out of 17 inflammatory substances presented in Table 3 are shown as 2 proteins, GRO-alpha and YKL-40, were presented twice in different biofluids. Data is presented as mean (range) where significant differences between groups (p < 0.05) are denoted with *, see "Regression of class discriminating inflammatory substances" section for exact figure