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Table 3 Significant cytokines in respective biofluid identified by OPLS-DA

From: The inflammatory profile of cerebrospinal fluid, plasma, and saliva from patients with severe neuropathic pain and healthy controls-a pilot study

Cytokine/chemokine

Biofluid

Up or down regulated in patients

VIP

p(corr)

MIP-1α

Saliva

2.52

− 0.75

IL-6

Plasma

2.39

− 0.70

IL-1β

Saliva

1.52

− 0.69

IL-1RA

Plasma

2.31

− 0.68

TSLP

Saliva

2.20

− 0.65

MIP-3β

Plasma

2.00

− 0.59

MIP-1β

Saliva

1.92

− 0.57

GRO-alpha

Saliva

1.89

− 0.56

YKL-40

Plasma

1.90

− 0.56

M-CSF

Saliva

1.86

− 0.55

MCP-3

Plasma

1.83

− 0.54

YKL-40

Saliva

1.80

− 0.54

IL-18

Saliva

1.79

− 0.53

CTACK

CSF

1.72

0.50

IL-13

CSF

1.77

0.52

ENA-78

Plasma

2.07

0.60

GRO-alpha

Plasma

2.07

0.61

  1. Negative p(corr) indicates higher levels in patients while a positive p(corr) indicates the opposite. The cytokines are listed by descending order of importance in respect to absolute p(corr).