Fig. 5

The addition of Q-VD-OPH did not affect the amount of cell death seen in male-derived slices (a). Exposure to Q-VD-OPH, at all concentrations tested, significantly reduced the amount of cell death in CA1 and DG regions compared to DMSO under OGD conditions in female-derived slices only (b, *P < 0.05 vs. DMSO). Exposure to PJ-34 did not affect the amount of cell death seen in female-derived slices (c). Treatment with PJ-34, at all concentrations tested, significantly reduced the amount of cell death in CA1 and DG regions compared to distilled water (DW) in male-derived slices only (d, *P < 0.05 vs. DW). Data are expressed as mean ± SEM and n = 8 independent wells