Sex-dimorphic neuroestradiol regulation of ventromedial hypothalamic nucleus glucoregulatory transmitter and glycogen metabolism enzyme protein expression in the rat

Table 4 Summary of Rostro-Caudal patterns of aromatase control of ventromedial hypothalamic nucleus (VMN) metabolic transmitter, glycogen metabolic, and pyruvate recycling pathway enzyme protein expression in eu- and hypoglycemic male versus female rats

^a Intracerebroventricular (icv) vehicle (V) infusion days 5–11; subcutaneous (sc) vehicle (V) injection day 11
^b icv V infusion days 5–11; sc 10.0 U neutral protamine Hagedorn insulin (INS)/kg bw injection day 11
^c icv letrozole (1.67 μg/μL dosage, 0.5 μL/h infusion rate) infusion days 5–11; sc V injection day 11
^d icv letrozole infusion days 5–11; sc INS injection day 11
^e V/INS vs V/V
^f Lz/V vs V/V
^g Lz/INS vs Lz/V
^h No change
ⁱ Neuronal nitric oxide synthase
^j Glutamate decarboxylase 65/67
^k Glycogen synthase
^l Glycogen phosphorylase-brain type
^m Glycogen phosphorylase-muscle type
ⁿ Glutaminase
^o Malic enzyme-1

ISSN: 1471-2202