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Table 3 Effects of letrozole (Lz) pretreatment on plasma glucose levels in vehicle (V)- or insulin (INS)-injected male and female rats

From: Sex-dimorphic neuroestradiol regulation of ventromedial hypothalamic nucleus glucoregulatory transmitter and glycogen metabolism enzyme protein expression in the rat

Sex Treatment groupse
V/Va V/INSb Lz/Vc Lz/INSd
Male 174.5 ± 11.1 75.3 ± 4.1* 182.3 ± 8.9 72.8 ± 2.3*
Female 169.7 ± 5.9 60.3 ± 3.8* 148.2 ± 7.1*** 79.5 ± 4.5**
  1. a Intracerebroventricular (icv) V infusion days 5–11; subcutaneous (sc) V injection day 11
  2. b icv V infusion days 5–11; sc neutral protamine Hagedorn insulin (INS; 10 U/kg bw) day 11
  3. c icv letrozole (Lz; 1.67 µg/µL dosage, 0.5 µL/h infusion rate) infusion days 5–11; sc V injection day 11
  4. d icv Lz infusion days 5–11; sc INS injection day 11
  5. e F(7/40) = 68.61; p < 0.0001
  6. * p < 0.0001 versus V-injected controls
  7. ** p < 0.005 versus V-injected controls
  8. *** p < 0.001 Lz/V-M versus Lz/V-F