Sex-dimorphic neuroestradiol regulation of ventromedial hypothalamic nucleus glucoregulatory transmitter and glycogen metabolism enzyme protein expression in the rat

Table 3 Effects of letrozole (Lz) pretreatment on plasma glucose levels in vehicle (V)- or insulin (INS)-injected male and female rats

^a Intracerebroventricular (icv) V infusion days 5–11; subcutaneous (sc) V injection day 11
^b icv V infusion days 5–11; sc neutral protamine Hagedorn insulin (INS; 10 U/kg bw) day 11
^c icv letrozole (Lz; 1.67 µg/µL dosage, 0.5 µL/h infusion rate) infusion days 5–11; sc V injection day 11
^d icv Lz infusion days 5–11; sc INS injection day 11
^e F_(7/40) = 68.61; p < 0.0001
* p < 0.0001 versus V-injected controls
** p < 0.005 versus V-injected controls
*** p < 0.001 Lz/V-M versus Lz/V-F

ISSN: 1471-2202