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Table 1 Nerve regeneration after nerve injury and repair in healthy and diabetic rats

From: Correction to: Gender differences in nerve regeneration after sciatic nerve injury and repair in healthy and in type 2 diabetic Goto-Kakizaki rats

 

Healthy

Male

(n = 10)

Healthy

Female

(n = 10)

Diabetes

Male

(n = 10)

Diabetes

Female

(n = 10)

p-values

(KWa)

Fisher’s methodb

Male/

female

Healthy/

Diabetes

Axonal outgrowth (neurofilaments, mm)

7.0

(6.8–7.3)

6.3

(6.1–6.4)

6.9

(6.7–7.1)

5.8

(5.1–6.2)

0.0001

 < 0.0001

0.02

ATF-3 (% of total) SNL

17.8

(17.6–18.4)

17.6

(16.7–18.0)

19.8

(19.1–21.1)

16.4

(15.7–17.3)

0.0001

0.0001

0.001

ATF-3 (% of total) SND

19.2

(17.7–19.6)

19.5

(18.9–20.1)

18.7

(16.9–20.1)

15.2

(14.4–15.7)

0.0001

0.0003

0.001

Cleaved caspase-3 (% of total) SNL

5.2

(2.6–7.8)

3.1

(2.9–3.4)

9.6

(8.7–11.6)

7.0

(6.4–10.1)

0.0001

0.31

 < 0.0001

Cleaved caspase-3 (% of total) SND

2.7

(2.2–4.0)

2.5

(2.4–2.7)

6.4

(4.5–7.1)

5.8

(4.3–6.1)

0.0001

0.39

 < 0.0001

Total cell number (mm2) SNL

5344

(5297–5367)

4935

(4827–5010)

5043

(4916–5184)

5118

(4977–5161)

0.0001

0.0005

0.0001

Total cell number (mm2) SND

5344

(5273–5414)

5226

(5020–5391)

4949

(4789–5128)

5137

(4911–5179)

0.0001

0.07

 < 0.0001

Preoperative B-glucose (mmol/l)

4.6

(4.3–4.9)

3.90

(3.8–4.3)

15.0

(13.3–17.2)

10.3

(9.7–11.7)

0.0001

 < 0.0001

 < 0.0001

Weight increase (%)

2.2

(0.7–2.7)

2.4

(1.3–4.8)

2.0

(1.2–2.6)

2.6

(2.0–3.2)

0.34

–

–

  1. Values are median 25th (Q1)−75th (Q3) percentiles. p-values in italics is significantly different at least at the 0.05 level. aKW = Kruskal–Wallis. bFisher method for independent samples based on the chi square distribution. SNL site of lesion, SND distal nerve segment. Total cell = DAPI stained cells