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Table 7 Multiple regression analysis to demonstrate the association of structural and functional parameters of SOD1 variants and their correlation with ALS

From: Does conserved domain SOD1 mutation has any role in ALS severity and therapeutic outcome?

Coefficients

Dependent variable: PROVEAN Score

 

Unstandardized coefficients

 

Standardized coefficients

T

P

 

B

Std. Error

beta

  

(Constant)

−13.98

2.891

 

−4.836

0

QMEAN

3.299

1.058

0.358

3.119

0.003

Dependent variable: QMEAN

 (Constant)

2.921

0.065

 

44.757

0

 PROVEAN Score

0.037

0.012

0.336

3.025

0.004

 Eco DDG DynaMut

−0.156

0.063

−0.274

−2.47

0.016

Dependent variable: DDG iMutant value

 (Constant)

−1.376

0.127

 

−10.811

0

 Eco Entropy Dynamut

−0.582

0.244

−0.281

−2.382

0.02

Dependent variable: PolyPhen-2 Score

 (Constant)

0.621

0.076

 

8.14

0

 PROVEAN Score

−0.054

0.014

−0.429

−3.863

0.02