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Table  3 Tabular representation of PROVEAN, SIFT and PolyPhen-2 scores along with Gibb’s free energy and entropy values for studied variants which fall in average domain of SOD1 protein

From: Does conserved domain SOD1 mutation has any role in ALS severity and therapeutic outcome?

Mutation

DDG (Kcal/mol)

Stability

ΔΔG ENCoM kcal/mol

Stability

ΔΔSVib ENCoM (kcal.mol−1.K−1)

Mol flex

Provean

Eff.

RI

Eff.

SIFT

Eff.

Pphen2

Eff.

Reg.

I114T

−1.82

Dec

−0.345

Destab

0.43

Inc

−4.85

Del

4

Dis

0

APF

0.999

Pro. D

2b

I105F

−3.1

Dec

0.395

Destab

−0.49

Dec

−3.61

Del

8

Dis

0

APF

0.999

Pro. D

4

C7T

−0.13

Dec

0.114

Destab

−0.14

Dec

−7.92

Del

4

Dis

0.06

Tol

1

Pro. D

4

C7F

0.7

Inc

1.306

Stab

−1.63

Dec

−8.79

Del

8

Dis

0.01

APF

1

Pro. D

4

I152T

−3.12

Dec

−0.177

Destab

0.221

Inc

−3.98

Del

4

Dis

0.03

APF

0.969

Pro. D

4

G13R

−1.96

Dec

0.171

Destab

−0.21

Dec

−2.99

Del

6

Dis

0.03

APF

0.968

Pro. D

4

S106L

−2.1

Dec

−0.153

Destab

0.19

Inc

−4.89

Del

5

Dis

0.08

Tol

0.924

POS. D

4

S106L

−2.1

Dec

−0.153

Destab

0.19

Inc

−4.89

Del

2

Dis

0.08

Tol

0.924

POS. D

4

I113T

−2.42

Dec

−0.209

Destab

0.26

Inc

−4.72

Del

6

Dis

0

APF

1

Pro. D

2b

I36F

−0.51

Dec

0.517

Stab

−0.65

Dec

−3.46

Del

7

Dis

0.02

APF

0.998

Pro. D

4

F65L

−1.44

Dec

−0.396

Destab

0.495

Inc

−5.70

Del

5

Dis

0

APF

0.995

Pro. D

5