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Table 1 Tabular representation QMEAN, Cβ, solubility and torsion obtained from SWISS model algorithm and domain location of studied SOD1 variants

From: Does conserved domain SOD1 mutation has any role in ALS severity and therapeutic outcome?

Mutation

ConSurf

Nature

QM

All atom

Solv

Tor

Mutation

ConSurf

Nature

QM

All atom

Solv

Tor

L39V

Con.

NP

2.67

2.71

−0.89

0.38

2.15

V149G

Con.

NP

2.46

2.98

−0.85

0

2.02

G38R

Con

PB

1.77

2.45

−0.97

0.33

1.28

G148D

Con.

PA

2.53

2.7

−1.02

0.39

2.01

Q23R

Con.

PB

2.56

2.68

−0.96

0.36

2.06

N140L

Con.

NP

2.37

2.56

−1.09

0.37

1.88

Q23L

Con.

NP

2.89

2.9

−0.96

0.37

2.36

V149I

Con.

NP

2.69

2.82

−0.9

0.42

2.14

N87S

Con.

P

2.69

2.75

−0.96

0.33

2.19

T55R

Con.

PB

2.72

2.71

−0.9

0.41

2.2

N87I

Con.

NP

2.5

2.64

−0.87

0.46

1.96

S135N

Con.

P

2.55

2.73

−0.87

0.33

2.04

G42S

Con.

P

2.04

2.9

−0.92

0.38

1.45

S135T

Con.

P

2.72

2.43

−0.93

0.32

2.29

G42D

Con.

PA

2.13

2.87

−0.97

0.38

1.56

L85V

Con.

NP

2.67

2.72

−0.93

0.37

2.16

H44R

Con.

PB

2.36

2.51

−0.93

0.33

1.89

G17S

Con.

P

2.52

2.65

−1.04

0.23

2.07

G86S

Con.

P

2.01

2.79

−0.9

0.28

1.48

G17C

Con.

P

2.55

2.57

−1.07

0.21

2.13

G86R

Con.

PB

2.35

2.39

−1.06

0.32

1.92

L127S

Con.

P

2.9

3.11

−0.8

0.33

2.33

L107V

Con.

NP

2.73

2.8

−0.88

0.35

2.21

I114T

Avg.

P

2.75

2.69

−0.92

0.29

2.28

L107F

Con.

NP

2.45

2.28

−0.89

0.33

2.03

I105F

Avg.

NP

2.65

2.57

−0.94

0.27

2.21

A5V

Con.

NP

2.55

2.79

−0.92

0.23

2.07

C7T

Avg.

P

2.44

2.75

−0.9

0.27

1.95

H47R

Con.

PB

2.72

2.71

−0.91

0.24

2.26

C7F

Avg.

NP

2.43

2.41

−0.96

0.1

2.07

A5T

Con.

P

2.56

2.56

−0.97

0.24

2.13

I152T

Avg.

P

2.59

2.71

−0.88

0.34

2.08

A5S

Con.

P

2.82

2.65

−0.93

0.32

2.34

G13R

Avg.

PB

2.52

3.09

−0.87

0.59

1.84

A146T

Con.

P

2.52

2.84

−1.05

0.26

2.02

S106L

Avg.

NP

2.49

2.82

−0.98

0.36

1.96

G73S

Con.

P

2.42

2.46

−0.92

0.26

1.99

S106L

Avg.

NP

2.49

2.82

−0.98

0.36

1.96

G73C

Con.

P

2.54

2.45

−0.91

0.3

2.1

I113T

Avg.

P

2.7

2.76

−0.97

0.34

2.19

F46S

Con.

P

2.76

2.84

−0.93

0.35

2.24

I36F

Avg.

NP

2.64

2.61

−1.08

0.29

2.19

F46C

Con.

P

2.79

2.75

−0.96

0.37

2.29

F65L

Avg.

NP

2.71

2.89

−0.89

0.36

2.17

H81R

Con.

PB

2.69

2.79

−0.89

0.3

2.18

E101G

Var

NP

2.53

2.49

−1.01

−0.05

2.21

I150T

Con.

P

2.47

2.69

−0.92

0.34

1.97

L145S

Var

P

2.61

2.71

−0.86

0.32

2.12

V119L

Con.

NP

2.57

2.71

−0.88

0.35

2.06

E22K

Var

PB

2.61

2.47

−1.12

0.37

2.16

A90V

Con.

NP

2.82

2.8

−1.03

0.22

2.36

D97N

Var

P

2.67

2.71

−0.87

0.3

2.18

R116G

Con.

NP

2.82

2.59

−0.93

0.41

2.33

L145F

Var

NP

2.66

2.85

−0.91

0.36

2.12

R116C

Con.

P

2.56

2.57

−0.98

0.47

2.04

G74R

Var

PB

2.49

2.59

−0.98

0.24

2.04

L85F

Con.

NP

2.6

2.71

−0.93

0.28

2.12

D91A

Var

NP

2.52

2.99

−0.78

0.27

1.98

V88A

Con.

NP

2.57

2.68

−0.89

0.22

2.11

N20S

Var

P

2.7

2.76

−0.81

0.36

2.18

I150T

Con.

P

2.47

2.69

−0.92

0.34

1.97