From: Does conserved domain SOD1 mutation has any role in ALS severity and therapeutic outcome?
Mutation | ConSurf | Nature | QM | Cβ | All atom | Solv | Tor | Mutation | ConSurf | Nature | QM | Cβ | All atom | Solv | Tor |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
L39V | Con. | NP | 2.67 | 2.71 | −0.89 | 0.38 | 2.15 | V149G | Con. | NP | 2.46 | 2.98 | −0.85 | 0 | 2.02 |
G38R | Con | PB | 1.77 | 2.45 | −0.97 | 0.33 | 1.28 | G148D | Con. | PA | 2.53 | 2.7 | −1.02 | 0.39 | 2.01 |
Q23R | Con. | PB | 2.56 | 2.68 | −0.96 | 0.36 | 2.06 | N140L | Con. | NP | 2.37 | 2.56 | −1.09 | 0.37 | 1.88 |
Q23L | Con. | NP | 2.89 | 2.9 | −0.96 | 0.37 | 2.36 | V149I | Con. | NP | 2.69 | 2.82 | −0.9 | 0.42 | 2.14 |
N87S | Con. | P | 2.69 | 2.75 | −0.96 | 0.33 | 2.19 | T55R | Con. | PB | 2.72 | 2.71 | −0.9 | 0.41 | 2.2 |
N87I | Con. | NP | 2.5 | 2.64 | −0.87 | 0.46 | 1.96 | S135N | Con. | P | 2.55 | 2.73 | −0.87 | 0.33 | 2.04 |
G42S | Con. | P | 2.04 | 2.9 | −0.92 | 0.38 | 1.45 | S135T | Con. | P | 2.72 | 2.43 | −0.93 | 0.32 | 2.29 |
G42D | Con. | PA | 2.13 | 2.87 | −0.97 | 0.38 | 1.56 | L85V | Con. | NP | 2.67 | 2.72 | −0.93 | 0.37 | 2.16 |
H44R | Con. | PB | 2.36 | 2.51 | −0.93 | 0.33 | 1.89 | G17S | Con. | P | 2.52 | 2.65 | −1.04 | 0.23 | 2.07 |
G86S | Con. | P | 2.01 | 2.79 | −0.9 | 0.28 | 1.48 | G17C | Con. | P | 2.55 | 2.57 | −1.07 | 0.21 | 2.13 |
G86R | Con. | PB | 2.35 | 2.39 | −1.06 | 0.32 | 1.92 | L127S | Con. | P | 2.9 | 3.11 | −0.8 | 0.33 | 2.33 |
L107V | Con. | NP | 2.73 | 2.8 | −0.88 | 0.35 | 2.21 | I114T | Avg. | P | 2.75 | 2.69 | −0.92 | 0.29 | 2.28 |
L107F | Con. | NP | 2.45 | 2.28 | −0.89 | 0.33 | 2.03 | I105F | Avg. | NP | 2.65 | 2.57 | −0.94 | 0.27 | 2.21 |
A5V | Con. | NP | 2.55 | 2.79 | −0.92 | 0.23 | 2.07 | C7T | Avg. | P | 2.44 | 2.75 | −0.9 | 0.27 | 1.95 |
H47R | Con. | PB | 2.72 | 2.71 | −0.91 | 0.24 | 2.26 | C7F | Avg. | NP | 2.43 | 2.41 | −0.96 | 0.1 | 2.07 |
A5T | Con. | P | 2.56 | 2.56 | −0.97 | 0.24 | 2.13 | I152T | Avg. | P | 2.59 | 2.71 | −0.88 | 0.34 | 2.08 |
A5S | Con. | P | 2.82 | 2.65 | −0.93 | 0.32 | 2.34 | G13R | Avg. | PB | 2.52 | 3.09 | −0.87 | 0.59 | 1.84 |
A146T | Con. | P | 2.52 | 2.84 | −1.05 | 0.26 | 2.02 | S106L | Avg. | NP | 2.49 | 2.82 | −0.98 | 0.36 | 1.96 |
G73S | Con. | P | 2.42 | 2.46 | −0.92 | 0.26 | 1.99 | S106L | Avg. | NP | 2.49 | 2.82 | −0.98 | 0.36 | 1.96 |
G73C | Con. | P | 2.54 | 2.45 | −0.91 | 0.3 | 2.1 | I113T | Avg. | P | 2.7 | 2.76 | −0.97 | 0.34 | 2.19 |
F46S | Con. | P | 2.76 | 2.84 | −0.93 | 0.35 | 2.24 | I36F | Avg. | NP | 2.64 | 2.61 | −1.08 | 0.29 | 2.19 |
F46C | Con. | P | 2.79 | 2.75 | −0.96 | 0.37 | 2.29 | F65L | Avg. | NP | 2.71 | 2.89 | −0.89 | 0.36 | 2.17 |
H81R | Con. | PB | 2.69 | 2.79 | −0.89 | 0.3 | 2.18 | E101G | Var | NP | 2.53 | 2.49 | −1.01 | −0.05 | 2.21 |
I150T | Con. | P | 2.47 | 2.69 | −0.92 | 0.34 | 1.97 | L145S | Var | P | 2.61 | 2.71 | −0.86 | 0.32 | 2.12 |
V119L | Con. | NP | 2.57 | 2.71 | −0.88 | 0.35 | 2.06 | E22K | Var | PB | 2.61 | 2.47 | −1.12 | 0.37 | 2.16 |
A90V | Con. | NP | 2.82 | 2.8 | −1.03 | 0.22 | 2.36 | D97N | Var | P | 2.67 | 2.71 | −0.87 | 0.3 | 2.18 |
R116G | Con. | NP | 2.82 | 2.59 | −0.93 | 0.41 | 2.33 | L145F | Var | NP | 2.66 | 2.85 | −0.91 | 0.36 | 2.12 |
R116C | Con. | P | 2.56 | 2.57 | −0.98 | 0.47 | 2.04 | G74R | Var | PB | 2.49 | 2.59 | −0.98 | 0.24 | 2.04 |
L85F | Con. | NP | 2.6 | 2.71 | −0.93 | 0.28 | 2.12 | D91A | Var | NP | 2.52 | 2.99 | −0.78 | 0.27 | 1.98 |
V88A | Con. | NP | 2.57 | 2.68 | −0.89 | 0.22 | 2.11 | N20S | Var | P | 2.7 | 2.76 | −0.81 | 0.36 | 2.18 |
I150T | Con. | P | 2.47 | 2.69 | −0.92 | 0.34 | 1.97 |