Fig. 2

Autoreceptors effect the distribution of eht values in the systems population model. In our systems population model we varied the strength of fire(t) and the \(V_{max}\) values of Trypin, TPH, AADC, MAT, MAO, Uptake 2, and SERT by 25%. a Shows the distribution of eht if there is no autoreceptor effect (pink bars) or if the autoreceptor effect is twice as strong as normal (blue bars). The green bars in b show the distribution of eht if the autoreceptor effect is “normal” (12.5 for the slope of inhib and 2.5 for the slope of inhibsyn). The green bars are similar to distributions measured in the Hashemi Lab (data not shown). The yellow bars show the distribution of eht if blood tryptophan is lowered from its normal value of \(96\upmu \hbox {M}\) to \(50\upmu \hbox {M}\). The distribution of eht moves substantially lower