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Table 1 Sensitivity and specificity of five anti-TDP FTD scFvs based on reactivity with FTD-TDP (n = 12), FTD-tau (n = 12) and control sera (n = 8)

From: Isolation and characterization of antibody fragments selective for human FTD brain derived TDP-43 variants

scFv FTD-TDP FTD-Tau Total
Sensitivity (%) Specificity (%) AUC Sensitivity (%) Specificity (%) AUC Sensitivity (%) Specificity (%) AUC
FTD-TDP1 91.66 100 0.99 75 75 0.85 75 87.5 0.92
FTD-TDP2 75 100 0.87 75 100 0.82 75 100 0.84
FTD-TDP3 100 87.5 0.99 91.66 87.5 0.96 95.83 100 0.99
FTD-TDP4 100 83.3 0.97 75 75 0.79 75 87.5 0.88
FTD-TDP5 100 100 1 100 100 1 100 100 1
  1. Sensitivity and specificity were calculated for FTD-TDP, FTD-tau and both FTD subtypes–AUC values greater than 0.95 are highlighted