Table 1 Results of the post hoc tests for rs11787922 (the original test is included as a point of reference)
Test | Description of the test | Test statistic | Effect of T allele on TROG-2 score, where relevant | P value |
|---|---|---|---|---|
Original test from the paternal parent-of-origin discovery analysis | This test compares two models, where only the full model includes the effect of only paternally-derived alleles. The likelihoods of the two models are then compared using a likelihood ratio test (χ2 statistic). | χ2 = 32.76; df = 1 | − 23.05 | 1.04 × 10−8 |
Test for the difference between paternal and maternal alleles | This test compares two models, where the null model already has the X = within = between family component from the “total” association model, and the full model includes, in addition to X, the effect of only maternally-derived alleles. The likelihoods of the two models are then compared using a likelihood ratio test (χ2 statistic). | χ2 = 20.7; df = 1 | 5 × 10−6 | |
Paternal parent-of-origin test with covariates for ASD, ADHD, and index family status | This test compares two models, where only the full model includes the effect of only paternally-derived alleles. Both models include the effects of the covariates. The likelihoods of the two models are then compared using a likelihood ratio test (χ2 statistic). | χ2 = 30.55; df = 1 | − 21.3 | 3.25 × 10−8 |
Paternal parent-of-origin test with a covariate for sex | This test compares two models, where only the full model includes the effect of only paternally-derived alleles. Both models include the effect of the covariate. The likelihoods of the two models are then compared using a likelihood ratio test (χ2 statistic). | χ2 = 32.61; df = 1 | − 22.9 | 1.13 × 10−8 |
Paternal parent-of-origin test using Z-scores of the transformed TROG-2 scores | This test compares two models, where only the full model includes the effect of only paternally-derived alleles. The likelihoods of the two models are then compared using a likelihood ratio test (χ2 statistic). | χ2 = 24.28; df = 1 | 8.33 × 10−7 | |
A test for the presence of a parent-of-origin effect in unrelated individuals | This test compares the trait variance of the heterozygous group to those of the homozygous groups. | \(\frac{{\hat{b}}}{{SE_{b} }}\;\sim \;N\;\left( {0,1} \right) \; = \;0. 2 6 6 4/0.0 8 9 8\) | 0.0016 |