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Fig. 4 | BMC Neuroscience

Fig. 4

From: MicroRNA-138 promotes neuroblastoma SH-SY5Y cell apoptosis by directly targeting DEK in Alzheimer’s disease cell model

Fig. 4

MiR-138 mediated suppression of DEK increased susceptibility of cell apoptosis. a Pre-treatment with miR-138 significantly decreased the level of p-Akt and upregulated the levels of cleaved caspase-3. b Quantitative analysis of p-Akt and cleaved caspase-3 protein levels from a, normalized to GAPDH protein level. c Effects of miRNA-138 on cell apoptosis induced by Aβ42 were assessed by flow cytometry. d Quantification of the percentage of apoptotic cells after exposure to Aβ42 in the presence of miRNA-138 mimic and/or miRNA-138 inhibitor. e Cell apoptosis observed by Hoechst 33258 staining using a fluorescence microscope (200×). Scale bar, 100 μm. f Percentage of apoptotic cells. *P < 0.05, **P < 0.01

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