Resuscitation with macromolecular superoxide dismutase/catalase mimetic polynitroxylated PEGylated hemoglobin offers neuroprotection in guinea pigs after traumatic brain injury combined with hemorrhage shock

Table 1 Arterial pH, blood gases, and blood glucose concentration of guinea pigs

Parameter	End surgery	1 h	2 h	3 h
pH
Sham	7.18 ± 0.07	7.33 ± 0.03*	7.32 ± 0.04*	7.30 ± 0.02*
TBI + HS + LR	7.20 ± 0.05	7.41 ± 0.04	7.43 ± 0.07	7.39 ± 0.03
TBI + HS + PNPH	7.21 ± 0.05	7.39 ± 0.02	7.42 ± 0.04	7.40 ± 0.04
PCO₂ (mmHg)
Sham	42 ± 4	32 ± 2	30 ± 3	32 ± 3
TBI + HS + LR	45 ± 8	30 ± 3	28 ± 6	30 ± 3
TBI + HS + PNPH	45 ± 7	31 ± 4	32 ± 4	32 ± 2
PO₂ (mmHg)
Sham	79 ± 19*	109 ± 8	106 ± 7	89 ± 11
TBI + HS + LR	159 ± 68	108 ± 16	116 ± 13	108 ± 15
TBI + HS + PNPH	188 ± 104	109 ± 27	126 ± 22	111 ± 24
Glucose (mg/dL)
Sham	145 ± 148	86 ± 34	77 ± 18	84 ± 20
TBI + HS + LR	149 ± 107	111 ± 43	105 ± 24	108 ± 30
TBI + HS + PNPH	162 ± 46	114 ± 47	96 ± 42	90 ± 29

HS hemorrhagic shock, LR lactated Ringer’s solution, PCO₂ partial pressure of carbon dioxide, PNPH polynitroxylated PEGylated hemoglobin, PO₂ partial pressure of oxygen, TBI traumatic brain injury. *P < 0.05 versus TBI + HS + LR and versus TBI + HS + PNPH

ISSN: 1471-2202