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Fig. 5 | BMC Neuroscience

Fig. 5

From: Resuscitation with macromolecular superoxide dismutase/catalase mimetic polynitroxylated PEGylated hemoglobin offers neuroprotection in guinea pigs after traumatic brain injury combined with hemorrhage shock

Fig. 5

Representative cresyl violet-stained sections of CA1 + 2 hippocampus from a naïve guinea pig with no surgery, a sham-operated guinea pig, and guinea pigs subjected to TBI and hemorrhagic shock (HS) followed by resuscitation with lactated Ringer’s solution (LR) or PNPH. Naïve and sham: Nissl-positive cells in the naïve group and sham group had normal morphology and intact nucleolus, indicating viable neurons. TBI + HS + LR: CA1 + 2 region had areas of cell loss accompanied by neutrophil infiltration. In some cases, a loose arrangement of cell bodies was observed, though the morphology of individual neurons looked normal. Red arrows show dead neurons with dark staining. TBI + HS + PNPH: Neurons in the CA1 + 2 region usually showed the normal compact arrangement. Insets in each image show higher magnification of boxed area. Scale bars = 50 μm

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