TY - JOUR AU - Park, Sung-su AU - Lee, Da-hye AU - Lee, So Min AU - Lee, Chang Ho AU - Kim, So Young PY - 2020 DA - 2020/04/25 TI - Noise exposure alters MMP9 and brevican expression in the rat primary auditory cortex JO - BMC Neuroscience SP - 16 VL - 21 IS - 1 AB - This study aimed to investigate the changes in molecules related to perineuronal nets (PNNs) and synaptic transporters in the primary auditory cortices of rats with noise-induced hearing loss. Female Sprague–Dawley rats at postnatal day 7 were divided into the noise and control groups. Four hours of 115 dB SPL white noise was delivered for 10 days to the noise group. Thirty days after noise exposure, the primary auditory cortex and the inferior colliculus were harvested. The expression levels of vesicular glutamatergic transporter (VGLUT)1, VGLUT2, vesicular GABA transporter (VGAT), glutamate decarboxylase (GAD)67, brevican, aggrecan, MMP9, and MMP14 were evaluated using real-time reverse transcription polymerase chain reaction or western blot. An immunofluorescence assay was conducted to assess parvalbumin (PV), Wisteria floribunda agglutinin (WFA), and brevican. The immune-positive cells were counted in the primary auditory cortex. SN - 1471-2202 UR - https://doi.org/10.1186/s12868-020-00567-3 DO - 10.1186/s12868-020-00567-3 ID - Park2020 ER -