Fig. 5

Injection of C-afferent irritator capsaicin into the sciatic nerve results in prompt vasodilatation in the foot that does not further increase in response to transection of the nerve. a Experimental schedule. b Representative perfusion images before and after transection of the left sciatic nerve. c Before-after line chart showing the change of blood perfusion in the foot. Data are expressed as mean ± SEM (n = 6 rats) and analyzed with repeated measures (mixed model) ANOVA followed by Bonferroni’s post hoc test. P < 0.001 for interaction between the group factor and the time factor, and for difference between capsaicin and vehicle before nerve transection (n.t.)