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Fig. 1 | BMC Neuroscience

Fig. 1

From: The role of C-afferents in mediating neurogenic vasodilatation in plantar skin after acute sciatic nerve injury in rats

Fig. 1

Sciatic nerve transection evokes prompt vasodilatation in the plantar aspect of the hind foot which rapidly decays in rats. a Schedule of experiments. The left sciatic nerve was transected at the mid-thigh level and laser Doppler perfusion imaging (LDPI) of the plantar aspect of both hind feet was performed before, 10 min after the nerve injury and then once daily for the following 6 days. b Representative LDPI images of the feet taken at indicated time. Color coding of the perfusion scale is shown at the bottom. c Bar chart with before-after lines showing the baseline perfusion in hind feet before injury. d Line chart demonstrating the change of blood perfusion in the hind feet of both sides from before to 7 days after transection of the left sciatic nerve. e One-phase decay curve fit of relative blood perfusion across time following nerve injury. Data are expressed as mean ± SEM (n = 8 rats) and analyzed with paired t test (c), repeated measures (mixed model) ANOVA followed by Bonferroni’s multiple comparison test (d) or non-linear regression and Spearman correlation (e). #P < 0.001 compared to the contralateral side at the same time point. Arrowheads indicate the side with sciatic nerve injury. n.s. non-significant

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