Table 1 Core genes set of cAMP-mediated dopamine response involved in the Ppp1r1b mediated phosphorylation cycles expanded with NMDA glutamate receptor set (Grina, Grin1-Grin2) and Map kinases genes
Gene symbol | Protein name | Description | STR–specifica |
|---|---|---|---|
Adcy5 | AC5 | Adenylate cyclase 5 | Yes |
Adora1 | A1A | Adenosine A1 receptor | No |
Adora2a | A2A | Adenosine A2a receptor | Yes |
Cdk5r1 | CDK5 | Cyclin-dependent kinase 5, regulatory subunit 1 (p35) | No |
Drd1 | D1R | Dopamine receptor D1 | Yes |
Drd2 | D2R | Dopamine receptor D2 | Yes |
Gnai2 | Gi/o | Guanine nucleotide binding protein (G protein), alpha inhibiting 2 | No |
Gnal | Golf | Guanine nucleotide binding protein, alpha stimulating, olfactory type | Yes |
Gpr88 | STRG | G-protein coupled receptor 88 | Yes |
Grin1 | NMDA1 | Glutamate receptor, ionotropic, NMDA1 (zeta 1) | No |
Grin2a | NMDA2A | Glutamate receptor, ionotropic, NMDA2A (epsilon 1) | No |
Grin2b | NMDA2B | Glutamate receptor, ionotropic, NMDA2B (epsilon 2) | No |
Grin2c | NMDA2C | Glutamate receptor, ionotropic, NMDA2C (epsilon 3) | No |
Grin2d | NMDA2D | Glutamate receptor, ionotropic, NMDA2D (epsilon 4) | No |
Grina | NMDARA1 | Glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) | No |
Map2k1 | ERK1 | Mitogen-activated protein kinase kinase 1 | No |
Map2k5 | ERK5 | Mitogen-activated protein kinase kinase 5 | No |
Mapk1 | ERK2 | Mitogen-activated protein kinase 1 | No |
Mapk3 | ERK1 | Mitogen-activated protein kinase 3 | No |
Mapk7 | ERK5 | Mitogen-activated protein kinase 7 | No |
Pde10a | ADSD2 | Phosphodiesterase 10A | Yes |
Pdyn | PPD | Prodynorphin | No |
Penk | PPE | Preproenkephalin | Yes |
Ppp1ca | PP1 | Protein phosphatase 1, catalytic subunit, alpha isoform | No |
Ppp1cb | protein phosphatase 1, catalytic subunit, beta isoform | No | |
Ppp1cc | Protein phosphatase 1, catalytic subunit, gamma isoform | No | |
Ppp1r1b | Darpp32 | Protein phosphatase 1, regulatory (inhibitor) subunit 1B | Yes |
Ppp2ca | PP2A | Protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform | No |
Ppp3ca | PP2B | Protein phosphatase 3, catalytic subunit, alpha isoform (Calcineurin) | No |
Prkaca | PKA | Protein kinase, cAMP dependent, catalytic, alpha | No |
Ptpn5 | STEP | Protein tyrosine phosphatase, non-receptor type 5 | Yes |
Tac1 | PPTA | Tachykinin 1 | Yes |
Tac2 | PPTB | Tachykinin 2 | No |