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Table 1 Core genes set of cAMP-mediated dopamine response involved in the Ppp1r1b mediated phosphorylation cycles expanded with NMDA glutamate receptor set (Grina, Grin1-Grin2) and Map kinases genes

From: Dopamine response gene pathways in dorsal striatum MSNs from a gene expression viewpoint: cAMP-mediated gene networks

Gene symbol Protein name Description STR–specifica
Adcy5 AC5 Adenylate cyclase 5 Yes
Adora1 A1A Adenosine A1 receptor No
Adora2a A2A Adenosine A2a receptor Yes
Cdk5r1 CDK5 Cyclin-dependent kinase 5, regulatory subunit 1 (p35) No
Drd1 D1R Dopamine receptor D1 Yes
Drd2 D2R Dopamine receptor D2 Yes
Gnai2 Gi/o Guanine nucleotide binding protein (G protein), alpha inhibiting 2 No
Gnal Golf Guanine nucleotide binding protein, alpha stimulating, olfactory type Yes
Gpr88 STRG G-protein coupled receptor 88 Yes
Grin1 NMDA1 Glutamate receptor, ionotropic, NMDA1 (zeta 1) No
Grin2a NMDA2A Glutamate receptor, ionotropic, NMDA2A (epsilon 1) No
Grin2b NMDA2B Glutamate receptor, ionotropic, NMDA2B (epsilon 2) No
Grin2c NMDA2C Glutamate receptor, ionotropic, NMDA2C (epsilon 3) No
Grin2d NMDA2D Glutamate receptor, ionotropic, NMDA2D (epsilon 4) No
Grina NMDARA1 Glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) No
Map2k1 ERK1 Mitogen-activated protein kinase kinase 1 No
Map2k5 ERK5 Mitogen-activated protein kinase kinase 5 No
Mapk1 ERK2 Mitogen-activated protein kinase 1 No
Mapk3 ERK1 Mitogen-activated protein kinase 3 No
Mapk7 ERK5 Mitogen-activated protein kinase 7 No
Pde10a ADSD2 Phosphodiesterase 10A Yes
Pdyn PPD Prodynorphin No
Penk PPE Preproenkephalin Yes
Ppp1ca PP1 Protein phosphatase 1, catalytic subunit, alpha isoform No
Ppp1cb protein phosphatase 1, catalytic subunit, beta isoform No
Ppp1cc Protein phosphatase 1, catalytic subunit, gamma isoform No
Ppp1r1b Darpp32 Protein phosphatase 1, regulatory (inhibitor) subunit 1B Yes
Ppp2ca PP2A Protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform No
Ppp3ca PP2B Protein phosphatase 3, catalytic subunit, alpha isoform (Calcineurin) No
Prkaca PKA Protein kinase, cAMP dependent, catalytic, alpha No
Ptpn5 STEP Protein tyrosine phosphatase, non-receptor type 5 Yes
Tac1 PPTA Tachykinin 1 Yes
Tac2 PPTB Tachykinin 2 No
  1. a‘Striatum (STR) -specific’ column indicates genes maintaining striatum specific expression preference