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Fig. 5 | BMC Neuroscience

Fig. 5

From: Diazepam and ethanol differently modulate neuronal activity in organotypic cortical cultures

Fig. 5

Relative changes in absolute power spectral density (PSD) or normalized PSD (nPSD) as induced by diazepam (DZP) or ethanol (EtOH). a DZP-induced changes in PSD: DZP concentration-dependently increases the power (i.e., the amplitude) in a wide range of frequencies. The grey and blue horizontal line indicate a significant effect of low (15 µM, grey) or high (30 µM, blue) DZP concentration vs. control (CNT). A horizontal bar in dark blue indicates a significant difference between 15 and 30 µM DZP. b DZP-induced changes in nPSD: The oscillatory composition did not change in a significant fashion, except for a narrow frequency range around 20 Hz for 15 µM DZP. c EtOH-induced changes in PSD: EtOH does not affect the power (i.e., the amplitude) in LFP oscillations. d EtOH-induced changes in nPSD: the oscillatory composition changed in a significant fashion towards a stronger contribution of higher frequencies above 10 Hz for the low EtOH concentration (30 mM) versus control as indicated by the horizontal bars. The solid trend lines indicate the median and the shaded areas the median absolute deviation. The horizontal bars indicate a significant difference (p < 0.05, Wilcoxon signed rank test) for the comparison indicated by the color of the bar

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