Table 3 Subcortical nuclei volume in Parkinson’s disease patients with mild to moderate and severe to very severe non-motor symptoms burden
PD mild to moderate NMS burden (NMSS = 0–40) | PD severe NMS burden (NMSS ≥ 41) | P value* | % change | |
|---|---|---|---|---|
Caudate (median ± SD) | 2.30 ± 0.2 | 2.40 ± 0.3 | > 0.10 | + 2.5 |
Putamen (median ± SD) | 3.30 ± 0.3 | 3.20 ± 0.3 | > 0.10 | − 3.6 |
Globus Pallidus (median ± SD) | 1.00 ± 0.2 | 1.00 ± 0.1 | > 0.10 | − 9.1 |
Thalamus (median ± SD) | 4.60 ± 0.4 | 4.20 ± 0.5 | 0.048 | − 9.1 |
Hippocampus (median ± SD) | 2.50 ± 0.3 | 2.40 ± 0.3 | > 0.10 | − 7.7 |
Amygdala (median ± SD) | 1.00 ± 0.1 | 0.96 ± 0.1 | 0.06 | − 11.3 |
Nucleus accumbens (median ± SD) | 0.30 ± 0.1 | 0.28 ± 0.1 | 0.06 | − 9.1 |