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Table 3 Subcortical nuclei volume in Parkinson’s disease patients with mild to moderate and severe to very severe non-motor symptoms burden

From: Sleep disturbances and gastrointestinal dysfunction are associated with thalamic atrophy in Parkinson’s disease

  PD mild to moderate NMS burden (NMSS = 0–40) PD severe NMS burden (NMSS ≥ 41) P value* % change
Caudate (median ± SD) 2.30 ± 0.2 2.40 ± 0.3 > 0.10 + 2.5
Putamen (median ± SD) 3.30 ± 0.3 3.20 ± 0.3 > 0.10 − 3.6
Globus Pallidus (median ± SD) 1.00 ± 0.2 1.00 ± 0.1 > 0.10 − 9.1
Thalamus (median ± SD) 4.60 ± 0.4 4.20 ± 0.5 0.048 − 9.1
Hippocampus (median ± SD) 2.50 ± 0.3 2.40 ± 0.3 > 0.10 − 7.7
Amygdala (median ± SD) 1.00 ± 0.1 0.96 ± 0.1 0.06 − 11.3
Nucleus accumbens (median ± SD) 0.30 ± 0.1 0.28 ± 0.1 0.06 − 9.1
  1. Italic values indicate the significant result P < 0.05
  2. * P values are Benjamini–Hochberg corrected for multiple comparisons