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Fig. 2 | BMC Neuroscience

Fig. 2

From: Altered activity in the nucleus raphe magnus underlies cortical hyperexcitability and facilitates trigeminal nociception in a rat model of medication overuse headache

Fig. 2

Effect of chronic treatment with acetaminophen on CSD development and modulating effect of muscimol microinjection into the NRM. Chronic treatment with acetaminophen significantly increased the number of cortical spreading depression (CSD) waves during the 30 min baseline period. In the saline-treated vehicle-control rats, the number of CSD waves within 90 min after the muscimol microinjection (15.7 ± 4.4; n = 7) was greater than that in the rats microinjected with saline vehicle control (10.9 ± 3.4; n = 7, p = 0.045). An enhancing effect of muscimol on CSD development was not observed in the acetaminophen-treated group. In the acetaminophen-treated group the number of CSD waves within 90 min after muscimol and saline microinjection was 17.3 ± 5.6 and 18.4 ± 5.8 respectively (p = 0.738). a Representative recordings comparing the effect of inhibiting the nucleus raphe magnus (NRM) with muscimol on CSD. b Scatterplots comparing the number of CSD waves after microinjection of muscimol or saline vehicle control into the NRM in the control group and the group of rats treated chronically with acetaminophen

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