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Fig. 5 | BMC Neuroscience

Fig. 5

From: The role of PI3K-mediated AMPA receptor changes in post-conditioning of propofol in brain protection

Fig. 5

Propofol post-conditioning promoted GluR2 trafficking to the postsynaptic membrane of neurons. A Electron micrographs of ischemic hippocampus from rats with IR injury (b, g), propofol post-conditioning (c, h), and Sham operation (a, f), LY294002 treated (d, i). In the S Group, some of GluR2 subunits located on cytomembrane (a) while some of them located on other membrane structure, such as mitochondria or endoplasmic reticulum (f). When the brain was suffered from IR injury, the GluR2 moved to the plasma (b, g); while propofol was given, most of GluR2 subunits returned back to the cytomembrane and postsynaptic membrane (c, h). In the LY294002 treated tissue, the GluR2 subunits is rare on the postsynaptic membrane but other membrane structure (d, i). The arrows showed the positive granules of GluR2 whose diameter was 1.4 nm and with lower transparency. M, cytomembrane; CP, cytoplasm; PM, postsynaptic membrane. Scale bars: a, b, c, d, g = 4 nm; f, h, i = 40 nm. B 9 neurons and 5 synapsis around were chosen randomly and the percentages of GluR2 subunits in the postsynaptic membrane were calculated by counting the positive granules in both cytoplasm and plasma membrane to reflect the trafficking of GluR2 subunits. In Group P, GluR2 located on postsynaptic membrane was more than that in Group IR (P = 0.20). S: sham-operated group; IR: P: propofol Post-cond group; L + P: LY294002 + propofol Post-cond group. n = 6 for each group. **P < 0.01 vs Group IR; #P < 0.05 vs Group P

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