Fig. 1

Propofol post-conditioning reduced the behavior deficit. Behavior tests showed propofol post-conditioning significantly improved function outcome. The mNSS in groups received propofol post-conditioning is significantly less than that in IR Group both at 11 h (P = 0.035) and 23 h (P = 0.042) after IR injury. Administration of LY294002 partly but significantly reversed the decrease in scores induced by propofol (P = 0.015 at 11 h, and P = 0.020 at 23 h after IR injury). n = 6 for each group. S: sham-operated group; IR: P: propofol Post-cond group; L + S: sham-operated group; L + IR: LY294002 + ischemia–reperfusion injury group; L + P: LY294002 + propofol Post-cond group. *P < 0.05 vs Group IR; ^#P < 0.05 vs Group P