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Fig. 14 | BMC Neuroscience

Fig. 14

From: Short-term dynamics of input and output of CA1 network greatly differ between the dorsal and ventral rat hippocampus

Fig. 14

μ-ORs modulate short-term synaptic plasticity in the DH but not in the VH. Short-term changes in fEPSP induced by stimulation of varying frequency are plotted as a function of stimulus number. The effects of activation of μ-ORs by fentanyl were examined at two stimulation current intensities: suprathreshold (circles) and submaximal (triangles) that caused a PS with amplitude 0.1–0.5 mV and 75% of maximal value respectively. The bottom right diagrams in the two panels (upper, DH and lower, VH) illustrate the average values of fEPSP changes produced by the 8th–10th stimuli (steady state response) plotted as a function of stimulation frequency. Data shown in the two stimulation intensities (suprathreshold and submaximal) were obtained from (slices/rats): 9/8 and 7/6 in the DH and 7/6 and 8/7 in the VH. Statistically significant drug effects observed only on responses evoked by suprathreshold stimulation are shown by horizontal bars (paired t-test of individual responses along the train, p < 0.05)

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