Fig. 12

Short-term dynamics of fEPSP and PS induced by suprathreshold stimulation in disinhibited DH (circles) and VH slices (diamonds). Data presented in a are the same as the data presented in Fig. 10 (PTX), and data presented in b are the same as the data shown in Fig. 11 (PTX). In this figure however data from DH and VH are plotted on the same graphs for facilitating comparisons of disinhibited responses between the two hippocampal segments. Statistically significant differences of responses evoked along the entire stimulation train, between the two hippocampal segments are shown by horizontal bars (MANOVA along entire train of responses and independent t-test of individual responses along the train, *p < 0.05, ***p < 0.005). Note that partial disinhibition produced by 5 μM PTX widens the differences in short-term synaptic plasticity between DH and VH by strongly increasing facilitation or reducing depression of fEPSP in DH (compare data in a with data shown in Fig. 3b). Also, the higher steady-state depression of PS observed in DH than in VH under control conditions is reversed into increased steady-state facilitation in DH at the stimulation frequency of 50 Hz (compare data in b with data shown in Fig. 5a)