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Fig. 2 | BMC Neuroscience

Fig. 2

From: Chronic exposure to high fat diet triggers myelin disruption and interleukin-33 upregulation in hypothalamus

Fig. 2

Microglia activation induced by chronic HFD feeding in hypothalamic arcuate nucleus. Mice at the age of 8 week old were fed by normal diet (Chow) and HFD for 3 and 4 months. a The images of immunostaining for Iba1 (red) and CD11b (green) in hypothalamic arcuate nucleus (ARC) at 3 and 4 months demonstrate the co-localization of Iba1+ cells with CD11b staining. The images with a high resolution are the representatives of Iba1+ cells co-localized with CD11b indicated in the insects. The cell numbers of microglia accumulated in ARC were quantified. The average of microglia cell number in ARC per mm2 was increased in the HFD group compared to those detected in the Chow group. c The averaged cell body size of ARC microglia was measured. Data are presented as mean ± SEM (n = 5 brain sections from 2 animals at each time point). **p < 0.01, ***p < 0.001 versus the Chow group. Scale bar in a 50 μm

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