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Table 1 Use of intravenous fluids, mean arterial pressure, and changes in laboratory values

From: Impact of inflammation on brain subcellular energetics in anesthetized rats

Variable Isoflurane groups Propofol groups
Sham (isoflurane) CLP (isoflurane) Sham vs. CLP Sham (propofol) CLP (propofol) Sham vs. CLP
Mean SD Mean SD p value Mean SD Mean SD p value
Fluids given (mL/kg) 6.91 2.11 13.21 3.32 0.004 11.89 6.21 20.85 5.71 0.001
MAP (start) 95.86 8.69 95.92 13.17 0.507 90.71 19.37 75.44 16.34 0.049
MAP (end) 102.38 8.71 77.06 23.08 0.001 82.35 12.78 67.23 16.61 0.020
MAP change 6.53 5.51 − 18.85 25.51 0.002 − 8.36 21.98 − 8.22 18.56 0.987
Lactate (start) 2.68 0.82 1.85 0.64 0.007 1.11 0.49 1.06 0.55 0.789
Lactate (end) 1.88 0.56 2.48 1.19 0.125 0.85 0.30 0.85 0.38 0.972
Lactate (change) − 0.80 0.72 0.64 1.48 0.006 − 0.26 0.60 − 0.21 0.69 0.843
Lactate (clearance) 27.58 22.71 − 50.88 84.40 0.005 − 1.20 77.69 − 3.72 86.06 0.931
BE (start) 4.92 4.14 4.75 4.14 0.922 7.42 2.81 6.50 2.11 0.197
BE (end) − 3.83 4.11 − 7.58 4.01 0.034 3.42 3.23 − 1.42 3.90 0.003
BE change − 8.75 2.99 − 12.33 5.96 0.076 − 4.00 4.69 − 7.92 2.94 0.023
Glucose (start) 379.33 85.57 396.75 86.98 0.626 375.75 50.83 373.17 92.47 0.665
Glucose (end) 200.33 43.81 159.42 85.93 0.156 136.17 25.21 113.42 22.50 0.019
Glucose change − 179.00 94.24 − 237.33 108.88 0.174 − 239.58 66.84 − 259.75 88.57 0.686
Anesth. dose 1.50 0.00 1.40 0.13 0.016 406.67 167.46 327.08 126.39 0.202
Cr (start) 0.28 0.05 0.30 0.10 0.421 0.25 0.10 0.25 0.08 0.801
Cr (end) 0.39 0.48 0.57 0.52 0.088 0.79 0.34 0.91 0.40 0.450
Cr (change) 0.12 0.47 0.27 0.50 0.128 0.54 0.35 0.66 0.41 0.459
Cr (clearance) − 38.89 155.59 − 94.86 183.41 0.121 − 242.36 160.08 − 290.28 200.56 0.524
BUN (start) 20.58 2.64 22.17 2.55 0.336 20.00 3.81 19.83 3.33 0.861
BUN (end) 39.75 17.49 48.25 17.28 0.244 34.08 6.26 40.33 10.71 0.026
BUN (change) 19.17 16.92 26.08 16.43 0.082 14.08 5.05 20.50 11.12 0.008
IL-6 (base) 145.00 50.79 146.05 33.92 0.957 67.12 22.87 51.04 24.82 0.104
IL-6 (8 h) 108.85 36.72 186.77 94.75 0.026 71.18 24.61 103.49 34.38 0.027
IL-6 difference − 36.14 60.25 40.72 102.63 0.056 4.06 37.77 52.44 38.03 0.011
TNF-a (base) 11.32 22.62 15.90 19.74 0.635 18.27 85.50 32.29 200.92 0.733
TNF-a (8 h) 25.26 21.85 66.09 45.97 0.021 − 17.79 25.99 305.22 205.95 0.000
TNF-a difference 13.94 34.75 50.19 47.14 0.066 − 36.06 95.83 272.93 269.44 0.003
IL-1B (base) 98.90 74.58 114.38 38.48 0.567 323.29 106.47 354.79 75.78 0.456
IL-1B (8 h) 101.73 58.06 153.34 41.77 0.035 309.60 95.37 625.25 398.89 0.026
IL-1B difference 2.84 40.46 38.96 41.35 0.088 − 13.69 90.66 270.46 428.46 0.055
  1. italic denotes a statistically significant difference between animals exposed to sepsis and controls