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Table 1 Patient characteristics

From: Electric stimulation of the medial forebrain bundle influences sensorimotor gaiting in humans

 

Patient #1

Patient #2

Patient #3

Disease duration [years]

6

5

6

Medication [years]

Donepezile 10 mg [3]

Donepezile 5 mg [1]

Gingko 240 mg [0.25]

Mirtazapine 30 mg [3]

Rivastigmine 9.5 mg [2]

Citalopram 20 mg [0.75]

Rivastigmine 9.5 mg [2]

Gingko 240 mg [0.5]

Severity of dementia

Mild AD, MMSE 27

Mild AD, MMSE 22

Moderate AD, MMSE 17

Clinical course

Slowly progressive with an increase of progression over the past year

Slowly progressive

Slowly progressive

Cognitive deficits

Encoding/consolidation memory, spatial and temporal orientation, executive functions

Encoding/consolidation memory, spatial and temporal orientation, visoconstructional skills

Encoding/consolidation memory, spatial and temporal orientation, visoconstructional skills, language, apraxia

MRI

Mild bilateral hippocampal atrophy

Moderate bitemporal atrophy including hippocampal atrophy

Global cortical atrophy

CSF

Amyloid beta ↓

Phosphorylated tau levels ↑

Amyloid beta ↓

Phosphorylated tau levels ↑

Amyloid beta ↓

Phosphorylated tau levels →