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Table 1 Patient characteristics

From: Electric stimulation of the medial forebrain bundle influences sensorimotor gaiting in humans

  Patient #1 Patient #2 Patient #3
Disease duration [years] 6 5 6
Medication [years] Donepezile 10 mg [3]
Donepezile 5 mg [1]
Gingko 240 mg [0.25]
Mirtazapine 30 mg [3]
Rivastigmine 9.5 mg [2]
Citalopram 20 mg [0.75]
Rivastigmine 9.5 mg [2]
Gingko 240 mg [0.5]
Severity of dementia Mild AD, MMSE 27 Mild AD, MMSE 22 Moderate AD, MMSE 17
Clinical course Slowly progressive with an increase of progression over the past year Slowly progressive Slowly progressive
Cognitive deficits Encoding/consolidation memory, spatial and temporal orientation, executive functions Encoding/consolidation memory, spatial and temporal orientation, visoconstructional skills Encoding/consolidation memory, spatial and temporal orientation, visoconstructional skills, language, apraxia
MRI Mild bilateral hippocampal atrophy Moderate bitemporal atrophy including hippocampal atrophy Global cortical atrophy
CSF Amyloid beta ↓
Phosphorylated tau levels ↑
Amyloid beta ↓
Phosphorylated tau levels ↑
Amyloid beta ↓
Phosphorylated tau levels →