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Fig. 5 | BMC Neuroscience

Fig. 5

From: Notch signalling defines dorsal root ganglia neuroglial fate choice during early neural crest cell migration

Fig. 5

DLL1 accumulation in Wnt1-Cre; Mib1fl/fl embryos reveals timing of DLL1-Notch signalling during early neural crest cell migration. a Transverse sections through the forelimb region of wildtype embryos at E9.25 (20 somite pairs) co-immunostained for DLL1 and the neural crest cell marker p75. Lower panel shows DLL1 staining alone for clarity. Inset image is a higher magnification of the boxed region. b Sections of Wnt1-Cre; Mib1fl/fl embryos at E9.25 co-immunostained for DLL1 and p75. Arrowheads indicate regions with increased DLL1 accumulation compared to wildtype. c, d Wildtype and Wnt1-Cre; Mib1fl/fl embryos at E9.5 (23 somites) co-immunostained for DLL1 and p75. e, f Wildtype and Wnt1-Cre; Mib1fl/fl embryos at E9.75 (26 somites) co-immunostained for DLL1 and the axonal/neuronal marker Tuj. g, h Wildtype and Wnt1-Cre; Mib1fl/fl embryos at E10.5 co-immunostained for DLL1 and Tuj, n = 3 embryos/genotype. nt neural tube; spn spinal nerve. All scale bars = 50 μm

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