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Fig. 3 | BMC Neuroscience

Fig. 3

From: Notch signalling defines dorsal root ganglia neuroglial fate choice during early neural crest cell migration

Fig. 3

Premature differentiation and aberrant cell death of Trk-positive neuronal subtypes in the DRG of Wnt1-Cre; Mib1fl/fl embryos (af). Transverse serial sections over the forelimb of wildtype and Wnt1-Cre; Mib1fl/fl embryos at E10.5 co-immunostained for the neuronal marker Isl1, cell death marker cleaved-Caspase 3 (Casp3), and the neurotrophin receptors TrkA (a, b), TrkB (c, d) and TrkC (e, f). Scale bar = 20 μm. g Quantitation of Trk and Isl1-double-positive cell bodies per DRG at E10.5. Number represents mean of n = 3 embryos, with 8 individual sections counted per embryo. *p < 0.05, **p < 0.01, ****p < 0.0001. hm Transverse serial sections over the forelimb of wildtype and Wnt1-Cre; Mib1fl/fl embryos at E11.5 co-immunostained for Isl1, Casp3, and TrkA (h, i), TrkB (j, k) and TrkC (l, m). Scale bar = 20 μm. n Quantitation of Trk and Isl1-double-positive cell bodies per DRG at E11.5. Number represents mean of n = 3 embryos, with 8 individual sections counted per embryo, ns not significant, *p < 0.05, ****p < 0.0001

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