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Fig. 4 | BMC Neuroscience

Fig. 4

From: Assessing the protective effect of rosiglitazone against electronic cigarette/tobacco smoke-induced blood–brain barrier impairment

Fig. 4

Protective effects of RSG against TS/EC-induced endothelial inflammation and loss of barrier integrity. a Immunofluorescence and Western blotting analysis demonstrating downregulation of TJ protein ZO-1 in cells treated with TS/EC and also increased expression of that in the cells including RSG. b TEER measurement after treatments demonstrated a significant loss of BBB integrity in cells treated with TS/EC, while RSG prevented the decrease in TEER. c Increase in dextran permeability measurements emphasizing the loss of BBB integrity in cells treated with TS/EC was prevented by RSG. n = 3 to 4 biological replicates. **p < 0.01, ***p < 0.001, ****p < 0.0001 versus control; +p < 0.05, ++p < 0.01, +++p < 0.001, ++++p < 0.0001 TS/EC versus TS/EC + RSG; $p < 0.05, $$$p < 0.001 EC versus TS. WB analyses report protein/β-actin ratios

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