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Fig. 3 | BMC Neuroscience

Fig. 3

From: Amyloid-β plaque formation and reactive gliosis are required for induction of cognitive deficits in App knock-in mouse models of Alzheimer’s disease

Fig. 3

Aβ deposition and reactive gliosis in brains of 24-month-old AppNL-G-F/NL-G-F and AppNL/NL mice. a Red rectangles in the schematic diagrams of mouse brain slice indicated brain regions selected for capturing immunofluorescent images. be Representative images of cortical and hippocampal regions from coronal brain sections immunostained with anti-Aβ 82E1 (magenta in be), anti-Iba1 (green in b and d) and anti-GFAP (green in c and e) were shown (blue in merged images indicated DAPI staining). b and c The magnified images captured from enclosed areas by the white rectangles in AppNL-G-F/NL-G-F mice were shown in the bottom panels. be AppNL-G-F/NL-G-F mice exhibited extensive microgliosis and astrocytosis associated with the aggressive Aβ plaque formation in the cortex and hippocampus. be AppNL/NL mice developed neither Aβ deposition nor neuroinflammation in the brain. n = 4 per genotype. Scale bar represents 500 μm for low-magnification images be and 20 μm for high-magnification images (bottom panels in b and c)

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