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Fig. 3 | BMC Neuroscience

Fig. 3

From: Pretreatment with a CRF antagonist amplifies feeding inhibition induced by fourth ventricular cocaine- and amphetamine-regulated transcript peptide

Fig. 3

A hypothetical auto-modulatory caudal brainstem mechanism for CARTp–CRF receptor interactions to affect feeding. We raise the hypothesis that CARTp may inhibit food intake via a putative receptor on a target neuron at some level in the dorsal hindbrain. CARTp could thus act via a CRF intermediate, which, via tonic lateral inhibition or perhaps via an inhibitory interneuron mechanism, attenuates the CARTp hypophagia. In the absence of stress activation, addition of a CRF antagonist would not by itself impact feeding but simply block CRF receptors, resulting in the loss of its tonic inhibition of the CARTp and subsequently in the unmasking of a full CARTp hypophagic behavioral response

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