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Fig. 2 | BMC Neuroscience

Fig. 2

From: Pretreatment with a CRF antagonist amplifies feeding inhibition induced by fourth ventricular cocaine- and amphetamine-regulated transcript peptide

Fig. 2

Antagonistic effect of αCRF (10 nmol) versus a high dose (1 nmol) of CRF agonist. Drugs and/or vehicle were administered fourth i.c.v. and solid food intake was measured at a 2 h, b 4 h and c 22 h, respectively. CRF suppressed food intake at 2 h and 4 h, respectively. This was blocked by αCRF, which did not produce any significant effect by itself at any time point, thus confirming the efficacy of the CRF antagonist in the current paradigm (NS not significant; *p < 0.05; ***p < 0.001)

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