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Fig. 1 | BMC Neuroscience

Fig. 1

From: Pretreatment with a CRF antagonist amplifies feeding inhibition induced by fourth ventricular cocaine- and amphetamine-regulated transcript peptide

Fig. 1

Pretreatment with the CRF antagonist effectively increased efficacy of CARTp-induced feeding suppression. a Effects over time of a subthreshold dose, and an effective dose of CARTp, αCRF, or CARTp after αCRF pretreatment, on ad libitum solid food intake over 22 h. Results at each separate time point are shown in panels bd; b food intake effects of 0.5 or 1 µg CARTp, 10 nmol αCRF, αCRF and respective CARTp-dose, or vehicle after 2 h, c 4 h and d 22 h (NS not significant; *p < 0.05; **p < 0.01; ***p < 0.001)

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