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Fig. 4 | BMC Neuroscience

Fig. 4

From: Astrocytes infected with Chlamydia pneumoniae demonstrate altered expression and activity of secretases involved in the generation of β-amyloid found in Alzheimer disease

Fig. 4

Protein expression of ADAM10, BACE1 and PSEN1 in Chlamydia pneumoniae-infected and uninfected astrocytes. Whole cell lysate was harvested from Cpn-infected and uninfected astrocytoma cells, resolved via SDS-PAGE gel electrophoresis, and labeled for secretase proteins. Fold change represents densitometry analysis for protein levels of full-length ADAM10, BACE1 and PSEN1 C-terminal fragment in Cpn-infected cells compared to that of uninfected cells at the same timepoint post infection. All densitometry values were normalized to that of β-actin for each biological replicate (N = 5–7). Statistical analysis was conducted using student’s T-test of fold change within each timepoint (asterisk indicates p < 0.05). Error bars represent standard error of the mean

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BMC Neuroscience

ISSN: 1471-2202

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