Exercise challenge alters Default Mode Network dynamics in Gulf War Illness

BMC Neuroscience

Table 2 Significant clusters of deactivation before the exercise stressors

Pre-exercise fMRI
Group	Cluster Size	T-score peak voxel	MNI Coordinates*
Controls (n = 10)
Bilateral dorsomedial prefrontal cortex	769	9.07	4, 44, 52 − 10, 50, 38 − 6, 40, 56
Left ventromedial prefrontal cortex	161	6.25	− 8, 50, − 14 − 2, 54, 4 − 10, 54, − 6
STOPP subjects (n = 18)
Bilateral dorsomedial prefrontal cortex	1413	6.11	− 2, 60, 12 4, 52, 44 − 6, 62, 22
START subjects (n = 10)
Right ventromedial prefrontal cortex	323	7.57	10, 54, 42 8, 54, 28

Prior to exercise, controls and GWI groups deactivated similar regions within the medial prefrontal cortex
* Greater than 1 reported MNI coordinate shows separate (> 8 mm apart) local maxima within a cluster. (P < 0.05, clusterwise corrected threshold; MNI coordinates x, y and z in mm)

ISSN: 1471-2202