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Fig. 5 | BMC Neuroscience

Fig. 5

From: Time dependent degeneration of the nigrostriatal tract in mice with 6-OHDA lesioned medial forebrain bundle and the effect of activin A on l-Dopa induced dyskinesia

Fig. 5

Activin A does not delay the onset of LIDs, a experimental design. Mice receive a 6-OHDA injection to develop a lesion over a 3 week period, before undergoing an amphetamine induced rotation test to assess the lesion magnitude. Based on the rotation score animals are split into 2 even groups and receive an osmotic micropump filled with either activin A or vehicle. The following day repeated l-Dopa injections start and AIMs are scored every 3rd day for 120 min. Activin A did not alter global AIMs score over a testing period of 19 days (b), during the monitoring session on the last day (c) or as a combination of axial, limb and orolingual scores during the last testing session (d). All values represent the mean ± SEM (control n = 17; activin A n = 15)

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